ArticleCancer discovery2020
Mutations in the RNA Splicing Factor SF3B1 Promote Tumorigenesis through MYC Stabilization.
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In one paragraph
Article in Cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Relationship between osteoporosis and benign paroxysmal positional vertigo based on evidence-based medicine and bioinformatics.Archives of osteoporosis · 2021Pooled it
- The Impact of SF3B1 Mutations on the Tumor Microenvironment and Response to Immunotherapy.Cancer medicine · 2026Article
- Splicing-driven post-translational dysregulation: a new frontier for precision cancer medicine and immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Role of alternative splicing in cancer progression.Irish journal of medical science · 2026Review
- Spliceosomal mutation drives melanoma tumorigenesis via lineage-specific RAS activation.Science advances · 2026Article
- Obesity-associated gene mutations across cancer types: a pan-cancer analysis of TCGA data.BJC reports · 2026Article
- Integrated Single-Cell analysis Reveals molecular correlation of maternal-to-zygotic transition between human and pig embryo.Journal of translational medicine · 2026Article
- De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders.Nature communications · 2026Article
- Mapping isoforms and regulatory mechanisms from spatial transcriptomics data with SPLISOSM.Nature biotechnology · 2026Article
- MYC-mediated transcriptional control of splicing factors promotes RNA splicing in activated B lymphocytes.Scientific reports · 2025Article
- Oncogenic DEAD-box ATPase DDX41 establishes transcript ensembles via CLK3-dependent and -independent mechanisms.Nature communications · 2025Article
- Distinct and convergent effects ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- mRNA Isoforms and Variants in Health and Disease.International journal of molecular sciences · 2025Review
- SF3B1 mutation accelerates the development of CLL via activation of the mTOR pathway.JCI insight · 2025Article
- SUGP1 loss drives SF3B1 hotspot mutant missplicing in cancer.Cell reports · 2025Article
- Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers.EMBO reports · 2025Article
- MRAS: Master Regulator Analysis of Alternative Splicing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Alternative Splicing in Tumorigenesis and Cancer Therapy.Biomolecules · 2025Review
- Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations.Scientific reports · 2025Article
- Low-risk MDS-A spotlight on precision medicine forHemaSphere · 2025Review
21 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 6 institutions in 2 countries.
Zhaoqi Liu *Program for Mathematical Genomics, Columbia University, New York, New York.
Akihide Yoshimi *Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York. rr2579@cumc.columbia.edu yoshimia@mskcc.org.ORCID https://orcid.org/0000-0002-0664-7281
Jiguang WangDivision of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.ORCID https://orcid.org/0000-0002-6923-4097
Hana ChoHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Stanley Chun-Wei LeeHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Michelle KiHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Lillian BitnerHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Timothy ChuProgram for Mathematical Genomics, Columbia University, New York, New York.
Harshal ShahHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID https://orcid.org/0000-0001-7556-0422
Bo LiuHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Anthony R MatoLeukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Peter RuvoloDivision of Cancer Medicine, Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Giulia FabbriInstitute for Cancer Genetics, Columbia University, New York, New York.
Laura PasqualucciInstitute for Cancer Genetics, Columbia University, New York, New York.
Omar Abdel-WahabHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Raul RabadanProgram for Mathematical Genomics, Columbia University, New York, New York. rr2579@cumc.columbia.edu yoshimia@mskcc.org.
Memorial Sloan Kettering Cancer Center · USColumbia University · USCancer Genetics (United States) · USColumbia University Irving Medical Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Hong Kong · HK
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MScientific ReagentsP01CA087497 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CORDON-CARDO, CARLOS · 2000 to 2021
$35.4MTopology of Cancer Evolution and HeterogeneityU54CA193313 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2015 to 2020
$10.4MGenetic and molecular basis for SRSF2 mutations in myelodysplasiaR01HL128239 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Omar Abdel-Wahab, Robert K Bradley · 2015 to 2026
$8.0MIdentification and modeling of driver genetic modules in glioblastomaR01CA179044 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2014 to 2018
$2.3M(PQB5) Reconstruction of Evolutionary Networks using Cross-Sectional Genomic DataR01CA185486 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LASORELLA, ANNA, RABADAN, RAUL · 2014 to 2017
$2.1MDefining Novel Genetic Dependencies in Spliceosome Mutant LeukemiaK99CA218896 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEE, STANLEY CHUN-WEI · 2017 to 2018
$297kNCI NIH HHS K99 CA218896NCI NIH HHS P01 CA087497NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA179044NCI NIH HHS R01 CA185486NCI NIH HHS U54 CA193313NHLBI NIH HHS R01 HL128239
Abstract
Although mutations in the gene encoding the RNA splicing factor SF3B1 are frequent in multiple cancers, their functional effects and therapeutic dependencies are poorly understood. Here, we characterize 98 tumors and 12 isogenic cell lines harboring
Indexed as
CarcinogenesisCell Transformation, NeoplasticHumansNeoplasmsPhosphoproteinsRNA Splicing FactorsPhosphoproteinsRNA Splicing FactorsSF3B1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.