Evidence map›Paper›PMID 32188692›Full record

ArticleThe Journal of biological chemistry2020

Effects of deficiency in the

Jose Ronaldo Lima de Carvalho, Hye Jin Kim, Keiko Ueda, Jin Zhao, Aaron P Owji, Tingting Yang, Stephen H Tsang, Janet R Sparrow

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 41 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. More insights from Abca4The Journal of biological chemistry · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Germline Disruption of Retinal Pigment Epithelium-Expressed Zebrafish rlbp1bFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  10. Transcriptomic Profiling of Zebrafish Mutant forInternational journal of molecular sciences · 2025
    Article
  11. Advances and therapeutic opportunities in visual cycle modulation.Progress in retinal and eye research · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Acyl-CoA:wax alcohol acyltransferase 2 modulates the cone visual cycle in mouse retina.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  17. The interplay of environmental luminance and genetics in the retinal dystrophy induced by the dominant RPE65 mutation.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. The Role of Vitamin A in Retinal Diseases.International journal of molecular sciences · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jose Ronaldo Lima de CarvalhoDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, New York 10032.
Hye Jin KimDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, New York 10032.
Keiko UedaDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, New York 10032.ORCID 0000-0002-3890-9565
Jin ZhaoDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, New York 10032.ORCID 0000-0002-1934-6445
Aaron P OwjiDepartment of Pharmacology, Columbia University Irving Medical Center, New York, New York 10032.
Tingting YangDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, New York 10032.ORCID 0000-0002-5220-588X
Stephen H TsangDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, New York 10032.
Janet R SparrowDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, New York 10032 jrs88@columbia.edu.
Columbia University Irving Medical Center · US

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
IMPACT OF LIPOFUSCIN IN RETINAL PIGMENT EPITHELIAL CELLSR01EY012951 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPARROW, JANET RUTHE · 2000 to 2024
$8.9M
Quantitative Fundus Autofluorescence in Retinal DisordersR01EY024091 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPARROW, JANET RUTHE · 2014 to 2022
$3.4M
Mechanistic Characterization of Calcium-Activated Chloride Channels in Retinal Pigment EpitheliumR01GM127652 · NIGMS · UNIVERSITY OF ROCHESTER · PI YANG, TINGTING · 2018 to 2022
$1.7M
Structure-function Analysis of BestrophinsR00EY025290 · NEI · UNIVERSITY OF ROCHESTER · PI YANG, TINGTING · 2016 to 2018
$747k
NEI NIH HHS P30 EY019007NEI NIH HHS R00 EY025290NEI NIH HHS R01 EY012951NEI NIH HHS R01 EY024091NIGMS NIH HHS R01 GM127652
6 · The paper itself

Abstract

Mutations in

Indexed as

MutationAdolescentAdultAnimalsAsymptomatic DiseasesCarrier ProteinsChildFemaleFundus OculiHeterozygoteHumansMaleMicePhenotypeRetinoidsVision Disorders11-cis-retinal-binding proteinCarrier ProteinsRetinoidsbisretinoidsCRALBPretinaretinal degenerationretinitis punctata albescensretinoidRLBP1visionvisual cyclevitamin A

Identifiers

PMID32188692
PMCPMC7212638
OpenAlexW3012502072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.