Evidence map›Paper›PMID 32188606›Full record

ArticleBMJ case reports2020

Symptomatic hyponatremia: a rare but reversible adverse reaction of lubiprostone.

Tsuneo Takenaka, Mikio Zeniya, Soichiro Miura, Takahiro Amano

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tsuneo TakenakaDepartment of Medicine, Kokusai Iryo Fukushi Daigaku Daigakuin - Tokyo Aoyama Campus, Minato-ku, Tokyo, Japan takenaka@iuhw.ac.jp.ORCID http://orcid.org/0000-0002-3383-1340
Mikio ZeniyaDepartment of Medicine, Kokusai Iryo Fukushi Daigaku Daigakuin - Tokyo Aoyama Campus, Minato-ku, Tokyo, Japan.
Soichiro MiuraDepartment of Medicine, Kokusai Iryo Fukushi Daigaku Daigakuin - Tokyo Aoyama Campus, Minato-ku, Tokyo, Japan.
Takahiro AmanoDepartment of Medicine, Kokusai Iryo Fukushi Daigaku Daigakuin - Tokyo Aoyama Campus, Minato-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several intestinal secretagogues became available for the patients with irritable bowel syndrome. We report a case of symptomatic hyponatremia after lubiprostone ingestion. A male patient was visiting our office to manage chronic kidney disease. He suffered chronic hepatitis (type C), which was successfully treated with asunaprevir and daclatasvir. He took lubiprostone due to constipation, and then watery diarrhoea was frequently developed. Next morning, he came to our hospital due to consciousness disturbance. Physical examination showed dehydration and laboratory data exhibited hyponatremia (110 mEq/L). Subsequent treatment against hypovolemic hyponatremia recovered his consciousness without any sequels. This case suggests that intestinal secretagogues can accompany severe electrolyte disturbance. Potential mechanisms for hyponatremia were discussed.

Indexed as

Hepatitis C, ChronicAgedChloride Channel AgonistsConstipationDiagnosis, DifferentialHumansHyponatremiaLubiprostoneMaleChloride Channel AgonistsLubiprostonechronic renal failuredrugs and medicineshepatitis Cneurology

Identifiers

PMID32188606
PMCPMC7078685
OpenAlexW3011156403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.