Evidence map›Paper›PMID 32188519›Full record

ArticlePsychological medicine2021

Within-person increase in pathological worry predicts future depletion of unique executive functioning domains.

Nur Hani Zainal, Michelle G Newman

Abstract read
In one paragraph

Article in Psychological medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
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  4. White Noise-Is Anxiety in Late-Life Associated With White Matter Hyperintensity Burden?The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nur Hani ZainalDepartment of Psychology, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0002-2023-3173
Michelle G NewmanDepartment of Psychology, The Pennsylvania State University, University Park, PA, USA.ORCID 0000-0003-0873-1409

Funding

U19 MIDlife in the United States-Diversity Supplement-WellsU19AG051426 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI CAROL D. RYFF · 2016 to 2026
$74.8M
STATISTICS COREP01AG020166 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI RYFF, CAROL D. · 2002 to 2015
$50.6M
Harnessing Mobile Technology to Reduce Mental Health Disorders in College PopulationsR01MH115128 · NIMH · WASHINGTON UNIVERSITY · PI EISENBERG, DANIEL, NEWMAN, MICHELLE G · 2018 to 2022
$4.1M
NIA NIH HHS P01 AG020166NIA NIH HHS U19 AG051426NIMH NIH HHS R01 MH115128
6 · The paper itself

Abstract

backgroundAffective neuroscience and scar theories propose that increased excessive worry, the hallmark symptom of generalized anxiety disorder (GAD), predicts future declines in executive functioning (EF). However, the preponderance of cross-sectional designs used to examine between-person chronic worry-EF relationships has blocked progress on understanding their potentially causal within-person associations. Accordingly, this study used bivariate dual latent change score (LCS) models to test whether within-person increased GAD severity might relate to future reduced EF.

methodsCommunity-dwelling adults (N = 2581, 46 years on average, s.d. = 11.40, 54.71% female) were assessed for GAD symptom severity (Composite International Diagnostic Interview-Short Form) across three waves, spaced about 9 years apart. Three aspects of EF [inhibition, set-shifting, and mixing costs (MCs; a measure related to common EF)], were assessed with stop-and-go switch tasks. Participants responded to 20 normal and 20 reverse single-task block trials and 32 mixed-task switch block trials. EF tests were administered at time 2 (T2) and time 3 (T3), but not at time 1 (T1).

resultsAfter controlling for T1 depression, LCS models revealed that within-person increased T1 - T2 GAD severity substantially predicted future reduced T2 - T3 inhibition and set-shifting (both indexed by accuracy and latency), and MC (indexed by latency) with moderate-to-large effect sizes (|d| = 0.51-0.96).

conclusionsResults largely support scar theories by offering preliminary within-person, naturalistic evidence that heightened excessive worry can negatively predict future distinct aspects of cognitive flexibility. Effectively targeting pathological worry might prevent difficulties arising from executive dysfunction.

Indexed as

AnxietyAnxiety DisordersCognitive DysfunctionCross-Sectional StudiesExecutive FunctionFemaleHumansIndependent LivingInhibition, PsychologicalMaleMiddle AgedAffective neuroscienceexecutive functioninggeneralized anxiety disorderlatent changeworry

Identifiers

PMID32188519
PMCPMC7501084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.