Evidence map›Paper›PMID 32188495›Full record

ArticleBMC research notes2020

Breast milk vitamin B12 concentration and incidence of diarrhea and respiratory infections among infants in urban Tanzania: a prospective cohort study.

Omar N Lweno, Christopher R Sudfeld, Ellen Hertzmark, Karim P Manji, Anne Marie Darling, Wafaie W Fawzi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Omar N LwenoIfakara Health Institute, Bagamoyo Research and Training Center, Bagamoyo, Tanzania. olweno@ihi.or.tz.
Christopher R SudfeldDepartments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ellen HertzmarkDepartments of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Karim P ManjiMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Anne Marie DarlingDepartments of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Wafaie W FawziDepartments of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard Global Health Institute · USHarvard University · USIfakara Health Institute · TZMuhimbili University of Health and Allied Sciences · TZ

Funding

Tanzania Infectious Disease Research Training ProgramD43TW007886 · FIC · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2007 to 2018
$1.9M
FIC NIH HHS D43 TW007886
6 · The paper itself

Abstract

objectiveA recent trial of vitamin B12 supplementation among Indian children 6-30 months found no effect on the incidence of diarrhea and respiratory infections. These results differ with studies in adults that showed improvement of the immune response following treatment with vitamin B12. We sought to determine how the adequacy of vitamin B12 concentrations in breast milk could act as immune modulator and protect against the incidence of diarrhea and respiratory infections of children up to 18 months in urban Tanzania.

resultsA prospective cohort study was undertaken to determine the association of breast milk vitamin B12 concentration with the incidence of acute respiratory infection and diarrhea among infants in urban Tanzania. A random sample of 491 women enrolled in a trial of multivitamins provided milk for B12 analysis at or around 6 weeks postpartum. Of 491 women, 345 had breast milk vitamin B12 inadequacy (< 310 pmol/L). Using generalized estimating equations, we found no overall association of milk vitamin B12 concentration with incident diarrhea and acute respiratory infections in infants. Studies measuring longitudinal changes of breast milk B12 concentration over time are needed to clarify the role of breast milk vitamin B12 in childhood infections.

Indexed as

Acute DiseaseAdolescentAdultBreast FeedingDiarrheaFemaleHumansIncidenceInfantLactationMaleMilk, HumanProspective StudiesRespiratory Tract InfectionsTanzaniaVitamin B 12Vitamin B 12Breast milkChildhood infectionsVitamin B12

Identifiers

PMID32188495
PMCPMC7081683
OpenAlexW3010947657

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.