ArticleThe journal of headache and pain2020
The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine.
Article in The journal of headache and pain, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The cerebellum in migraine: a narrative review of anatomical, imaging, and clinical evidence.Frontiers in neurology · 2026Pooled it
- Mapping structural and functional brain networks associated with migraine.The journal of headache and pain · 2026Article
- Potential neural mechanisms of acupuncture therapy on migraine: a systematic review and activation likelihood estimation meta-analysis update.Quantitative imaging in medicine and surgery · 2025Article
- Phasic perfusion dynamics among migraine subtypes: a multimodel arterial spin labeling investigation.The journal of headache and pain · 2024Article
- Acceleration of brain aging after small-volume infarcts.Frontiers in aging neuroscience · 2024Article
- Parahippocampus hypertrophy drives gray matter morphological alterations in migraine patients without aura.The journal of headache and pain · 2023Article
- Shared alterations in hippocampal structural covariance in subjective cognitive decline and migraine.Frontiers in aging neuroscience · 2023Article
- Consensus Paper: Novel Directions and Next Steps of Non-invasive Brain Stimulation of the Cerebellum in Health and Disease.Cerebellum (London, England) · 2022Article
- Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study.The journal of headache and pain · 2022Article
- Regional rather than global brain age mediates cognitive function in cerebral small vessel disease.Brain communications · 2022Article
- Cerebro-Cerebellar Networks in Migraine Symptoms and Headache.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Involvement of the cerebellum in migraine.Frontiers in systems neuroscience · 2022Review
- Altered Structural Covariance of Insula, Cerebellum and Prefrontal Cortex Is Associated with Somatic Symptom Levels in Irritable Bowel Syndrome (IBS).Brain sciences · 2021Article
- Assessment of normalized cerebral blood flow and its connectivity with migraines without aura during interictal periods by arterial spin labeling.The journal of headache and pain · 2021Article
- Somatosensory Gating Responses Are Associated with Prognosis in Patients with Migraine.Brain sciences · 2021Article
- Improving Individual Brain Age Prediction Using an Ensemble Deep Learning Framework.Frontiers in psychiatry · 2021Article
- Potential Alterations of Functional Connectivity Analysis in the Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome.Neural plasticity · 2021Article
- Is there a reliable brain morphological signature for migraine?The journal of headache and pain · 2020Article
- Functional Alterations in the Posterior Insula and Cerebellum in Migraine Without Aura: A Resting-State MRI Study.Frontiers in behavioral neuroscience · 2020Article
- Disrupted functional connectivity in the hippocampal subregions of patients with migraine without aura: a functional study on mechanisms underlying migraine chronification.Frontiers in neurologyArticle
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8 authors.
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Abstract
backgroundThe increase of headache frequency is associated with higher headache related disability and lower quality of life in patients with migraine. However, the pathophysiology of migraine progression, persistence, or remission is elusive. The purpose of this study is to identify the brain signatures that are predictive of the long-term outcomes among patients with high-frequency migraine (HFM: 10-30 headache days/month).
methodsWe prospectively enrolled patients with HFM and healthy controls and collected their baseline clinical profiles and brain-MRI data at first visit. We longitudinally followed the patients and determined their outcomes at 2-year follow-up. Good outcome was defined as ≥50% reduction of baseline headache days and poor outcome was defined as reduction < 50% or frequency increase. Voxel-based morphometry was used to study gray matter volume (GMV), and structural covariance was used to investigate structural connectivity.
resultsAmong 56 patients with HFM, 37 had good outcome and 19 poor outcome. Compared to the healthy controls (n = 37), patients with poor outcome had decreased GMV over the left posterior cingulate gyrus, and increased GMV over the bilateral cerebellum and the right precentral gyrus. Further, patients with poor outcome had greater GMV over the right and the left cerebella compared to patients with good outcome, and the GMVs of the cerebella were correlated to 2-year headache frequencies (right: r = 0.38, P = 0.005; left: r = 0.35, P = 0.009). Structural connectivity were increased between the cerebellum and the cuneus, the calcarine cortex, and the temporal lobe, respectively, in patients with poor outcome, and was decreased between the cerebellum and the prefrontal cortex in patients with poor outcome. The structural covariance integrities between the right cerebellum and the right cuneus were correlated to 2-year headache frequencies (r = 0.36, P = 0.008).
conclusionsStructural volume and connectivity changes of the cerebellum may underlie headache persistence in patients with HFM.
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