ArticleInternational journal of environmental research and public health2020
New Application of Osteogenic Differentiation from HiPS Stem Cells for Evaluating the Osteogenic Potential of Nanomaterials in Dentistry.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Regenerative Endodontic Treatment in an Immature Permanent Tooth With Necrotic Pulp and Periradicular Lesion.Clinical case reports · 2025Article
- Osteoblastic Differentiation of Stem Cells from Human Exfoliated Deciduous Teeth by Probiotic Hydroxyapatite.Cell journal · 2023Article
- Emerging Applications of Nanotechnology in Dentistry.Dentistry journal · 2023Review
- Effects of Laser Application on Alveolar Bone Mesenchymal Stem Cells and Osteoblasts: An In Vitro Study.Diagnostics (Basel, Switzerland) · 2022Article
- Pulp revascularization on an adult mandibular right second premolar: A case report.World journal of clinical cases · 2022Article
- Microstructure and Mechanical Properties of Inverse Nanocomposite Made from Polylactide and Hydroxyapatite Nanoparticles.Materials (Basel, Switzerland) · 2021Article
- Article
- Investigating the Antioxidant and Cytocompatibility ofInternational journal of environmental research and public health · 2021Article
- The Loop-Mediated Isothermal Amplification Technique in Periodontal Diagnostics: A Systematic Review.Journal of clinical medicine · 2021Review
- Effect of Nano-Filled Protective Coating and Different pH Enviroment on Wear Resistance of New Glass Hybrid Restorative Material.Materials (Basel, Switzerland) · 2021Article
- Evaluation of Root-End Preparation with Two Different Endodontic Microsurgery Ultrasonic Tips.Biomedicines · 2020Article
- Effect of Nanostructured Scaffold on Human Adipose-Derived Stem Cells: Outcome ofNanomaterials (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHiPS stem cells are commonly used for the study of medical disorders. Thelaboratory in which this study was conducted uses these cells for examining the treatment and cureof neurodegenerative diseases. Bone regeneration poses the greatest challenge for an oral surgeonboth in terms of increased implant osseointegration and reducing bone healing times. The aim ofthis study was to validate the protocol in the literature to produce and then test in vitro osteoblastswith different nanomaterials to simulate bone regeneration.
methodhiPS clones (#2, #4, and #8)were differentiated into an osteoblast cell culture tested for alizarin red staining and for alkalinephosphatase testing at 14, 21 and 28 days, after the cells were plated.
resultsThe cells showeddiffuse positivity under alizarin red staining and the alkaline phosphatase (ALP)-test, showingsmall formations of calcium clusters.
conclusionDespite the limitations of our study, it is a startingpoint for further protocols, laying a solid foundation for research in the field of bone regenerationthrough the use of stem cells. .
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