ArticleAntioxidants (Basel, Switzerland)2020
Effects of Bisphenol A on Oxidative Stress in the Rat Brain.
Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Kelulut honey (Toxicology reports · 2026Review
- A Natural Monoterpene, Carvacrol, Mitigates Bisphenol A-Triggered Hepatorenal Oxidative Damage, Pro-Inflammatory Gene Expression, and Histopathological Alterations in Rats.Life (Basel, Switzerland) · 2026Article
- Ultrasonic exposure enhances the body's antioxidant capacity.Journal of clinical biochemistry and nutrition · 2026Article
- Protective Effects ofFood science & nutrition · 2026Article
- Environmental endocrine disruptors at the synapse: mechanisms linking chemical exposure to cognitive and behavioral dysfunction.Frontiers in behavioral neuroscience · 2026Review
- Neuroprotective role of Nigella Sativa seed oil in mitigating bisphenol a-induced neurodegeneration.Scientific reports · 2025Article
- Therapeutic Effects of Naringin on Bisphenol A-Induced Oxidative Stress Damage in Nervous and Reproductive Systems of Cockerel Chickens.Veterinary medicine and science · 2025Article
- Role ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Ferulic acid ameliorates bisphenol A (BPA)-induced Alzheimer's disease-like pathology through Akt-ERK crosstalk pathway in male rats.Psychopharmacology · 2025Article
- Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu.Journal of xenobiotics · 2025Review
- Protective role of astaxanthin against bisphenol A induced biochemical and histopathological alterations in rat kidneys.Iranian journal of basic medical sciences · 2025Article
- Bisphenol-A (BPA) Impairs Hippocampal Neurogenesis via Inhibiting Regulation of the Ubiquitin Proteasomal System.Molecular neurobiology · 2023Article
- Bisphenol-S Influence on Oxidative Stress and Endocrine Biomarkers of Reproductive System: A Systematic Review and Meta-Analysis.International journal of preventive medicine · 2023Review
- Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model.Frontiers in cell and developmental biology · 2023Article
- Effects of High-Intensity Anaerobic Exercise on the Scavenging Activity of Various Reactive Oxygen Species and Free Radicals in Athletes.Nutrients · 2023Article
- Peripubertal Bisphenol A Exposure Imparts Detrimental Age-Related Changes in Body Composition, Cognition, and Hydrogen Sulfide Production Capacities.Antioxidants & redox signaling · 2022Article
- Tau Toxicity in Neurodegeneration.Molecular neurobiology · 2022Review
- An insight into bisphenol A, food exposure and its adverse effects on health: A review.Frontiers in nutrition · 2022Review
- Role of neurotoxicants in the pathogenesis of Alzheimer's disease: a mechanistic insight.Annals of medicine · 2021Review
- Bisphenol A Modulates Autophagy and Exacerbates Chronic Kidney Damage in Mice.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the effect of bisphenol A (BPA) on oxidative stress and tau-related proteins in adult rat brains. BPA (10 mg/L) was administered to rats for eight weeks through their drinking water. The reactive oxygen species (ROS) scavenging capacity for hydroxyl radicals in the plasma was reduced after two weeks. In the hippocampus, four and eight weeks of BPA increased the ratio of oxidized DJ-1/DJ-1 (PARK7). The ratio of phosphorylated-GSK3β/GSK3β and phosphorylated-AKT/AKT increased after one week of BPA treatment. The ratio of phosphorylated JNK/JNK and phosphorylated-ERK/ERK increased after eight weeks of BPA; the elevation could be related to tau phosphorylation. Protein phosphatase 2A (PP2A) in the hippocampus decreased after eight weeks of BPA treatment. At that time, SOD1 was significantly induced, but no changes in SOD2 expression were apparent in the hippocampus. Furthermore, the ratio of phosphorylated-tau (PHF-1, Ser396/ Ser404) to total tau level did not change. However, PHF-1 or other sites of tau could be phosphorylated after eight weeks in the hippocampi of rats. BPA induced systemic oxidative stress and could change ROS-induced signaling pathways in the brain. These results suggest that mitochondrial dysfunction possibly is not responsible for oxidative stress and neurodegeneration due to low doses of BPA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.