ReviewNutrients2020
Vitamin K Deficiency Bleeding in Infancy.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 142 citations in OpenAlex.
- Late Vitamin K Deficiency Bleeding Presenting as Subacute Subdural Hemorrhage in an Exclusively Breastfed Infant: A Preventable Life-Threatening Condition-A Case Report.Clinical case reports · 2026Article
- Neonatal Thromboembolic Disease: Clinical Spectrum and Emerging Evidence for Diagnostic and Therapeutic Strategies Addressing Unmet Needs.Journal of clinical medicine · 2026Review
- Investigation for Bleeding Disorders in Suspected Non-Accidental Intracranial Haemorrhage.Journal of paediatrics and child health · 2026Article
- Vitamin K Biochemistry and Pharmacokinetics: The Basis of Late Vitamin K Deficiency Intracranial Bleeding in Early Infancy.International journal of molecular sciences · 2026Review
- Large intracerebral hemorrhage in the setting of vitamin K prophylaxis refusal.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- A Case of Childhood Lupus Anticoagulant-Hypoprothrombinemia Syndrome with Diagnostic and Therapeutic Insight.Pediatric health, medicine and therapeutics · 2026Article
- Scoping review of micronutrient imbalances, clinical manifestations, and interventions.World journal of methodology · 2025Review
- Vitamin K Deficiency: Diagnosis and Management.Annals of laboratory medicine · 2025Review
- Vitamin K deficiency as a cause of oral bleeding in a dog with intestinal malabsorption due to lymphocytic-plasmacytic enteritis.Open veterinary journal · 2025Article
- Vitamin K deficiency bleeding in children with cholestatic liver disease: a systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2025Review
- Hereditary Combined Deficiency of Vitamin K-Dependent Clotting Factors Presenting as Postoperative Haemorrhage in A Syrian Adolescent: A Likely VKCFD Type 2 Phenotype.European journal of case reports in internal medicine · 2025Article
- Neonatal Presentation of Severe Hemophilia A: An Original Case Report and a Literature Review.Children (Basel, Switzerland) · 2024Article
- Article
- Vitamin K prophylaxis in neonates: comparing two different oral regimens.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Association between fat-soluble vitamins and metabolic syndromes in US adults: a cross-section study from NHANES database.BMC endocrine disorders · 2024Article
- Hemophagocytic Lymphohistiocytosis Triggered by Herpes Simplex Virus 1 and 2: A Narrative Review.Hematology reports · 2024Review
- Article
- Bioactive Components of Human Milk and Their Impact on Child's Health and Development, Literature Review.Nutrients · 2024Review
- Anticoagulant effects of protein C, protein S, and antithrombin levels on the protein C pathway in young children.International journal of hematology · 2024Article
- Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin K is essential for the synthesis of few coagulation factors. Infants can easily develop vitamin K deficiency owing to poor placental transfer, low vitamin K content in breast milk, and poor intestinal absorption due to immature gut flora and malabsorption. Vitamin K deficiency bleeding (VKDB) in infancy is classified according to the time of presentation: early (within 24 h), classic (within 1 week after birth), and late (between 2 week and 6 months of age). VKDB in infancy, particularly late-onset VKDB, can be life-threatening. Therefore, all infants, including newborn infants, should receive vitamin K prophylaxis. Exclusive breastfeeding and cholestasis are closely associated with this deficiency and result in late-onset VKDB. Intramuscular prophylactic injections reduce the incidence of early-onset, classic, and late-onset VKDB. However, the prophylaxis strategy has recently been inclined toward oral administration because it is easier, safer, and cheaper to administer than intramuscular injection. Several epidemiological studies have shown that vitamin K oral administration is effective in the prevention of VKDB in infancy; however, the success of oral prophylaxis depends on the protocol regimen and parent compliance. Further national surveillance and studies are warranted to reveal the optimal prophylaxis regimen in term and preterm infants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.