Evidence map›Paper›PMID 32187883›Full record

Trial reportCancer medicine2020

Clofarabine, cytarabine, and mitoxantrone in refractory/relapsed acute myeloid leukemia: High response rates and effective bridge to allogeneic hematopoietic stem cell transplantation.

Harinder Gill, Rita Yim, Herbert H Pang, Paul Lee, Thomas S Y Chan, Yu-Yan Hwang, Garret M K Leung, Ho-Wan Ip, Rock Y Y Leung, Sze-Fai Yip and 15 more

Open access · goldAbstract readClinical Trial, Phase II
In one paragraph

Trial report in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 3 countries.

Harinder GillDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0002-9551-4893
Rita YimDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Herbert H PangSchool of Public Health, The University of Hong Kong, Hong Kong SAR, China.
Paul LeeDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Thomas S Y ChanDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Yu-Yan HwangDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Garret M K LeungDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Ho-Wan IpDepartment of Pathology, Queen Mary Hospital, Hong Kong SAR, China.
Rock Y Y LeungDepartment of Pathology, Queen Mary Hospital, Hong Kong SAR, China.
Sze-Fai YipDepartment of Medicine, Tuen Mun Hospital, Hong Kong SAR, China.
Bonnie KhoDepartment of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, China.
Harold K K LeeDepartment of Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
Vivien MakDepartment of Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
Chi-Chung ChanDepartment of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, China.
June S M LauDepartment of Medicine, Queen Elizabeth Hospital, Hong Kong SAR, China.
Chi-Kuen LauDepartment of Medicine, Tseung Kwan O Hospital, Hong Kong SAR, China.
Shek-Yin LinDepartment of Medicine, United Christian Hospital, Hong Kong SAR, China.
Raymond S M WongDepartment of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong SAR, China.
Wa LiDepartment of Clinical Oncology, Prince of Wales Hospital, Hong Kong SAR, China.
Edmond S K MaDepartment of Pathology, Hong Kong Sanatorium and Hospital, Hong Kong SAR, China.
Jun LiDepartment of Infectious Diseases and Public Health, The City University of Hong Kong, Hong Kong SAR, China.
Gianni PanagiotouSchool of Biological Sciences, The University of Hong Kong, Hong Kong SAR, China.
Joycelyn P Y SimDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Albert K W LieDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Yok-Lam KwongDepartment of Medicine, The University of Hong Kong, Hong Kong SAR, China.ORCID 0000-0001-8156-6978
University of Hong Kong · HKPrince of Wales Hospital · CNPrincess Margaret Hospital · HKQueen Elizabeth Hospital · CNQueen Mary Hospital · CNDepartment of Health · CNHong Kong Sanatorium and Hospital · HKLeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DEPamela Youde Nethersole Eastern Hospital · CNTseung Kwan O Hospital · CNTuen Mun Hospital · CNUnited Christian Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clofarabine is active in refractory/relapsed acute myeloid leukemia (AML). In this phase 2 study, we treated 18- to 65-year-old AML patients refractory to first-line 3 + 7 daunorubicin/cytarabine induction or relapsing after 3 + 7 induction and high-dose cytarabine consolidation, with clofarabine (30 mg/m

Indexed as

Drug Resistance, NeoplasmHematopoietic Stem Cell TransplantationAdultAgedAntineoplastic Combined Chemotherapy ProtocolsChemotherapy-Induced Febrile NeutropeniaClofarabineCytarabineDisease-Free SurvivalFemaleHumansLeukemia, Myeloid, AcuteMaleMiddle AgedMitoxantroneNeoplasm Recurrence, LocalClofarabineCytarabineMitoxantroneacute myeloid leukemiaadultclofarabinecytarabinemitoxantronerefractoryrelapsed

Identifiers

PMID32187883
PMCPMC7221314
OpenAlexW3010820032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.