ArticleDepression and anxiety2020
Positive and negative valence systems in major depression have distinct clinical features, response to antidepressants, and relationships with immunomarkers.
Article in Depression and anxiety, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis finds that psychological well-being predicts all-cause mortality independently of psychological ill-being.BMC public health · 2026Pooled it
- Validating an aphasia-accessible ecological momentary assessment for daily depressive affect: A preliminary investigation.Journal of affective disorders · 2026Article
- Measuring affective symptoms of depression in aphasia: development of an accessible ecological momentary assessment tool.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Article
- Multicentre development and two-stage validation of a patient-reported outcome measure for chronic obstructive pulmonary disease.iScience · 2026Article
- The most important features in generalized additive models might be groups of features.Scientific reports · 2026Article
- Two-week prevalence and correlates of suicidal ideation among first-visit general-hospital psychiatric outpatients: a cross-sectional study using the PHQ-9 and EPQ.BMC psychiatry · 2026Article
- Neural reactivity to infant faces and trait mindfulness as prospective predictors of postpartum depressive symptoms.Cognitive, affective & behavioral neuroscience · 2026Article
- The Research Domain Criteria (RDoC) domains positive valence system, negative valence system, cognitive systems, and social processes and their relationship with stress, anxiety, and depressive symptoms in a university student sample.Frontiers in psychiatry · 2026Article
- Digital Twin Brain: Generating Multitask Behavior from Connectomes for Personalized Therapy.BME frontiers · 2026Article
- The power of positivity: Exploring affective and social processes of change throughout a positive valence treatment for anxiety or depression.Journal of mood and anxiety disorders · 2025Article
- Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.Psychiatry research. Neuroimaging · 2025Review
- Investigating depression pathways in a clinical sample: childhood adversity, reward, and threat processing.Frontiers in psychology · 2025Article
- Opportunities and challenges for the use of deep brain stimulation in the treatment of refractory major depression.Discover mental health · 2024Review
- Moving beyond descriptive nosology: an argument for negative valence systems disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Cognitive, Disability, and Treatment Outcome Implications of Symptom-Based Phenotyping in Late-Life Depression.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023Article
- Characterizing positive and negative valence systems function in adolescent depression: An RDoC-informed approach integrating multiple neural measures.Journal of mood and anxiety disorders · 2023Article
- Defining Clinical Trial Estimands: A Practical Guide for Study Teams with Examples Based on a Psychiatric Disorder.Therapeutic innovation & regulatory science · 2023Article
- Mood and anxiety disorders within the Research Domain Criteria framework of Positive and Negative Valence Systems: a scoping review.Frontiers in human neuroscience · 2023Article
- The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy.Emerging topics in life sciences · 2022Article
- Validation of a novel method of ultraviolet-induced cutaneous inflammation and its associations with anhedonia.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundHeterogeneity in major depressive disorder (MDD) is well recognized but not well understood. Core depressive features are reward and emotional symptoms, which reflect dysfunctions in the positive valence (PV) and negative valence (NV) systems, respectively. This study assessed whether PV and NV systems (based on selected symptoms) were associated with different clinical features, antidepressant response, and levels of immunomarkers in adults with MDD.
methodsThese analyses used data from combining medications to enhance depression outcomes study (N = 665; n = 166 for immunomarkers). PV and NV symptom scores were extracted from the clinician-rated 30-item Inventory of Depressive Symptomatology. Correlational analyses were conducted.
resultsPV and NV symptom scores were substantially associated with different clinical features. PV symptoms (impaired motivation, impaired energy, and anhedonia) were independently associated with female gender (p < .001), older age (p = .012), and higher cognitive and physical impairment (p < .001) according to the 7-item Cognitive and Physical Functioning Questionnaire. Conversely, NV symptoms (anxiety and interpersonal sensitivity) were independently associated with younger age (p = .013), more anxious comorbidities (p = .001 for generalized anxiety disorder and p = .002 for social phobia) and other commonly associated noncriterion symptoms (p < .001). Overall, PV symptoms were more responsive to antidepressants than NV symptoms (p < .0001; Cohen's d = .455). A PV symptom score was positively correlated with the concentration of three proinflammatory and one anti-inflammatory factor. In contrast, an NV symptom score was negatively associated with only one proinflammatory immunomarker.
conclusionsPV and NV system functions appear to be reflected in selected clinical symptoms that differentially relate to other clinical features, treatment outcomes, and immunological function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.