Evidence map›Paper›PMID 32187538›Full record

ArticleCell reports2020

Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes.

James N Sleigh, Andrew P Tosolini, David Gordon, Anny Devoy, Pietro Fratta, Elizabeth M C Fisher, Kevin Talbot, Giampietro Schiavo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 90 citations in OpenAlex.

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  15. Roles of C/EBPβ/AEP in Neurodegenerative Diseases.Current topics in medicinal chemistry · 2025
    Review
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  18. Review
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  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

James N SleighDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK. Electronic address: j.sleigh@ucl.ac.uk.
Andrew P TosoliniDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
David GordonNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Anny DevoyDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Pietro FrattaDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Elizabeth M C FisherDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
Kevin TalbotNuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Giampietro SchiavoDepartment of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK; UK Dementia Research Institute, University College London, London WC1E 6BT, UK; Discoveries Centre for Regenerative and Precision Medicine, University College London Campus, London WC1N 3BG, UK. Electronic address: giampietro.schiavo@ucl.ac.uk.
National Hospital for Neurology and Neurosurgery · GBUniversity College London · GBJohn Radcliffe Hospital · GBUniversity of Oxford · GB

Funding

Medical Research Council G0801110Medical Research Council MC_EX_MR/N501931/1Medical Research Council MR/M008606/1Medical Research Council MR/S006508/1Medical Research Council MR/S006990/1Motor Neurone Disease Association FISHER/APR14/874-792Motor Neurone Disease Association FISHER/OCT14/876-792Motor Neurone Disease Association FRATTA/JAN15/946-795Wellcome TrustWellcome Trust 103191/Z/13/ZWellcome Trust 107116/Z/15/Z
6 · The paper itself

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease resulting from a complex interplay between genetics and environment. Impairments in axonal transport have been identified in several ALS models, but in vivo evidence remains limited, thus their pathogenetic importance remains to be fully resolved. We therefore analyzed the in vivo dynamics of retrogradely transported, neurotrophin-containing signaling endosomes in nerve axons of two ALS mouse models with mutations in the RNA processing genes TARDBP and FUS. TDP-43

Indexed as

Axonal TransportSignal TransductionAmyotrophic Lateral SclerosisAnimalsDNA-Binding ProteinsEndosomesFemaleHumansMaleMice, Inbred C57BLMotor NeuronsMutationRNA-Binding Protein FUSSensory Receptor CellsDNA-Binding ProteinsRNA-Binding Protein FUSTardbp protein, mouseALSamyotrophic lateral sclerosisintravital imagingMNDmotor neuron diseaseRNA-binding proteinTARDBP

Identifiers

PMID32187538
PMCPMC7090381
OpenAlexW3012177925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.