Evidence map›Paper›PMID 32187522›Full record

ArticleTrends in endocrinology and metabolism: TEM2020

Mitochondrial Complex I Inhibition by Metformin: Drug-Exercise Interactions.

S Martín-Rodríguez, P de Pablos-Velasco, J A L Calbet

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in endocrinology and metabolism: TEM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
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  6. Article
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  8. Article
  9. Metabolic Strategies for Inhibiting Cancer Development.Advances in nutrition (Bethesda, Md.) · 2021
    Review
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  11. Diabetes Mellitus, Mitochondrial Dysfunction and CaInternational journal of molecular sciences · 2020
    Review
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  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

S Martín-RodríguezDepartment of Physical Education, University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain. Electronic address: saulmrguez@gmail.com.
P de Pablos-VelascoResearch Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain; Department of Endocrinology and Nutrition, Hospital Universitario de Gran Canaria Doctor Negrín, 35010 Las Palmas de Gran Canaria, Spain.
J A L CalbetDepartment of Physical Education, University of Las Palmas de Gran Canaria, 35017 Las Palmas de Gran Canaria, Spain; Research Institute of Biomedical and Health Sciences (IUIBS), 35017 Las Palmas de Gran Canaria, Spain; Department of Physical Performance, Norwegian School of Sport Sciences, Postboks, 4014 Ulleval Stadion, 0806 Oslo, Norway.
Universidad de Las Palmas de Gran Canaria · ESHospital Universitario de Gran Canaria Doctor Negrín · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metformin has antidiabetic, anticancer, and prolongevity effects, but seems to interfere with aerobic training mitochondrial adaptations. The primary mechanism of action has been suggested to be the inhibition of mitochondrial complex I. Recent papers (Wang et al. and Cameron et al.), however, provide evidence to deny the hypothesis of a direct action of metformin on complex I.

Indexed as

MetforminExerciseHumansHypoglycemic AgentsMitochondriaOxidation-ReductionHypoglycemic AgentsMetforminexercisemetforminmitochondrial complex I

Identifiers

PMID32187522
OpenAlexW3008737718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.