ArticleMenopause (New York, N.Y.)2020
Executive function after risk-reducing salpingo-oophorectomy in BRCA1 and BRCA2 mutation carriers: does current mood and early life adversity matter?
Article in Menopause (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 49 citations in OpenAlex.
- Treating new-onset cognitive complaints after risk-reducing salpingo-oophorectomy: A randomized controlled crossover trial of lisdexamfetamine.Gynecologic oncology · 2024Trial
- Incarcerated adolescents scoring high on the Brown Attention-Deficit Disorder Scale are characterized by impairments within brain regions associated with executive control: A source-based morphometry study.Psychiatry research. Neuroimaging · 2025Article
- Reproducible sex differences in personalised functional network topography in youth.The British journal of psychiatry : the journal of mental science · 2025Article
- Reproducible Sex Differences in Personalized Functional Network Topography in Youth.bioRxiv : the preprint server for biology · 2024Article
- Effects of Hormonal Replacement Therapy and Mindfulness-Based Stress Reduction on Climacteric Symptoms Following Risk-Reducing Salpingo-Oophorectomy.Healthcare (Basel, Switzerland) · 2024Article
- Depressed, stressed, and inflamed: C-reactive protein linked with depression symptoms in midlife women with both childhood and current life stress.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Article
- Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner.Biology of sex differences · 2023Article
- Adverse childhood experiences and hormonal contraception: Interactive impact on sexual reward function.PloS one · 2023Article
- The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling.Nature communications · 2022Article
- Adverse childhood experiences interact with inflammation and menopause transition stage to predict verbal memory in women.Brain, behavior, & immunity - health · 2022Article
- Promoting brain health through physical activity among adults exposed to early life adversity: Potential mechanisms and theoretical framework.Neuroscience and biobehavioral reviews · 2021Review
- Impact of childhood adversity on network reconfiguration dynamics during working memory in hypogonadal women.Psychoneuroendocrinology · 2020Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveDespite the fact that negative mood and executive dysfunction are common after risk-reducing salpingo-oophorectomy (RRSO), occurring in up to a third of women, little is known about risk factors predicting these negative outcomes. Adverse childhood experiences (ACE) predict poorer health in adulthood and may be a risk factor for negative outcomes after RRSO. Given the complex relationship between early life stress, affective disorders, and cognitive dysfunction, we hypothesized that ACE would be associated with poorer executive function and that mood symptoms would partially mediate this relationship.
methodsWomen who had undergone RRSO were included in the study (N = 552; age 30-73 y). We measured executive function (continuous performance task, letter n-back task, and Brown Attention Deficit Disorder Scale Score), exposure to early life stress (ACE questionnaire), and mood symptoms (Hospital Anxiety and Depression Scale). Generalized estimating equations were used to evaluate the association between ACE and executive dysfunction and the role of mood symptoms as a mediator in this relationship.
resultsACE was associated with greater severity of subjective executive dysfunction (adjusted mean difference [aMD] = 7.1, P = 0.0005) and worse performance on both cognitive tasks (continuous performance task: aMD = -0.1, P = 0.03; n-back: aMD = -0.17, P = 0.007). Mood symptoms partially mediated ACE associations with sustained attention (21.3% mediated; 95% CI: 9.3%-100%) and subjective report of executive dysfunction (62.8% mediated; 95% CI: 42.3%-100%).
conclusionsThe relationship between childhood adversity and executive dysfunction is partially mediated by mood symptoms. These data indicate that assessing history of childhood adversity and current anxiety and depression symptoms may play a role in treating women who report cognitive complaints after RRSO. : Video Summary:http://links.lww.com/MENO/A571.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.