Evidence map›Paper›PMID 32186963›Full record

ArticleMolecular biology of the cell2020

Cellular homeostasis in the

Nigel W Griffiths, Lauren M Del Bel, Ronit Wilk, Julie A Brill

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Nigel W GriffithsCell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Lauren M Del BelCell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Ronit WilkCell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
Julie A BrillCell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.
University of Toronto · CAHospital for Sick Children · CA

Funding

CIHR MOP-119483
6 · The paper itself

Abstract

The complex functions of cellular membranes, and thus overall cell physiology, depend on the distribution of crucial lipid species. Sac1 is an essential, conserved, ER-localized phosphatase whose substrate, phosphatidylinositol 4-phosphate (PI4P), coordinates secretory trafficking and plasma membrane function. PI4P from multiple pools is delivered to Sac1 by oxysterol-binding protein and related proteins in exchange for other lipids and sterols, which places Sac1 at the intersection of multiple lipid distribution pathways. However, much remains unknown about the roles of Sac1 in subcellular homeostasis and organismal development. Using a temperature-sensitive allele (

Indexed as

AnimalsBiological TransportCarrier ProteinsCell MembraneDrosophila melanogasterDrosophila ProteinsEndoplasmic ReticulumHomeostasisMembrane ProteinsOxysterol Binding ProteinsPhosphatidylinositol PhosphatesPhosphoinositide PhosphatasesPhosphoric Monoester HydrolasesProtein TransportReceptors, SteroidRetinaCarrier ProteinsDrosophila ProteinsMembrane Proteinsmys protein, DrosophilaOxysterol Binding Proteinsphosphatidylinositol 4-phosphatePhosphatidylinositol PhosphatesPhosphoinositide PhosphatasesPhosphoric Monoester HydrolasesReceptors, SteroidSac1 protein, DrosophilaSterols

Identifiers

PMID32186963
PMCPMC7353163
OpenAlexW3012268158

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.