Evidence map›Paper›PMID 32186955›Full record

ArticleHuman vaccines & immunotherapeutics2020

Co-presence of Epstein-Barr virus and high-risk human papillomaviruses in Syrian colorectal cancer samples.

Mohammed I Malki, Ishita Gupta, Queenie Fernandes, Tahar Aboulkassim, Amber Yasmeen, Semir Vranic, Ala-Eddin Al Moustafa, Hamda A Al-Thawadi

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Mohammed I MalkiCollege of Medicine, QU Health, Qatar University , Doha, Qatar.
Ishita GuptaCollege of Medicine, QU Health, Qatar University , Doha, Qatar.
Queenie FernandesCollege of Medicine, QU Health, Qatar University , Doha, Qatar.
Tahar AboulkassimSegal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital , Montreal, Quebec, Canada.
Amber YasmeenSegal Cancer Centre, Lady Davis Institute for Medical Research of the Sir Mortimer B. Davis-Jewish General Hospital , Montreal, Quebec, Canada.
Semir VranicCollege of Medicine, QU Health, Qatar University , Doha, Qatar.
Ala-Eddin Al MoustafaCollege of Medicine, QU Health, Qatar University , Doha, Qatar.
Hamda A Al-ThawadiCollege of Medicine, QU Health, Qatar University , Doha, Qatar.
Qatar University · QAJewish General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently performed two studies exploring the presence of Epstein-Barr virus (EBV) and high-risk human papillomaviruses (HPVs) types 16, 18, 31, 33 and 35 in human colorectal cancers from the Syrian population. Herein, we report that EBV and high-risk HPVs are co-present in colorectal cancers from Syria. We reveal that 17 (~17%) of 102 cancer samples are positive for both EBV and high-risk HPVs and their co-presence is associated with high/intermediate grade invasive carcinomas. These data suggest that EBV and high-risk HPVs are co-present in human colorectal cancers where they might cooperate on the initiation and/or progression of these cancers. Thus, we believe that future studies are necessary to confirm the co-presence of these oncoviruses and their cooperative role in human colorectal carcinogenesis.

Indexed as

AlphapapillomavirusColorectal NeoplasmsEpstein-Barr Virus InfectionsPapillomavirus InfectionsHerpesvirus 4, HumanHumansSyriacancer phenotypecolorectal cancerEBVhigh-risk HPVSyrian population

Identifiers

PMID32186955
PMCPMC7644212
OpenAlexW3011858576

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.