Evidence map›Paper›PMID 32186918›Full record

ReviewAnnual review of biochemistry2020

Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems.

Alan R Davidson, Wang-Ting Lu, Sabrina Y Stanley, Jingrui Wang, Marios Mejdani, Chantel N Trost, Brian T Hicks, Jooyoung Lee, Erik J Sontheimer

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 158 citations in OpenAlex.

  1. How bacterial immune systems sense phage infection.Nature reviews. Microbiology · 2026
    Review
  2. Article
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  5. Review
  6. Article
  7. Review
  8. Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Avian PathogenicVeterinary sciences · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. The extended mobility of plasmids.Nucleic acids research · 2025
    Review

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Alan R DavidsonDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada; email: alan.davidson@utoronto.ca, sabrina.stanley@mail.utoronto.ca, priscilla.wang@utoronto.ca, chantel.trost@utoronto.ca.
Wang-Ting LuDepartment of Biochemistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada; email: wangting.lu@mail.utoronto.ca, marios.mejdani@mail.utoronto.ca, brian.hicks@mail.utoronto.ca.
Sabrina Y StanleyDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada; email: alan.davidson@utoronto.ca, sabrina.stanley@mail.utoronto.ca, priscilla.wang@utoronto.ca, chantel.trost@utoronto.ca.
Jingrui WangDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada; email: alan.davidson@utoronto.ca, sabrina.stanley@mail.utoronto.ca, priscilla.wang@utoronto.ca, chantel.trost@utoronto.ca.
Marios MejdaniDepartment of Biochemistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada; email: wangting.lu@mail.utoronto.ca, marios.mejdani@mail.utoronto.ca, brian.hicks@mail.utoronto.ca.
Chantel N TrostDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5G 1M1, Canada; email: alan.davidson@utoronto.ca, sabrina.stanley@mail.utoronto.ca, priscilla.wang@utoronto.ca, chantel.trost@utoronto.ca.
Brian T HicksDepartment of Biochemistry, University of Toronto, Toronto, Ontario M5G 1M1, Canada; email: wangting.lu@mail.utoronto.ca, marios.mejdani@mail.utoronto.ca, brian.hicks@mail.utoronto.ca.
Jooyoung LeeRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA; email: Jooyoung.Lee@umassmed.edu, Erik.Sontheimer@umassmed.edu.
Erik J SontheimerRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA; email: Jooyoung.Lee@umassmed.edu, Erik.Sontheimer@umassmed.edu.
Motorola (United States) · USUniversity of Toronto · CAUniversity of Massachusetts Chan Medical School · US

Funding

Enhancing Genome Editing Technology with Natural Cas9 InhibitorsR01GM125797 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SONTHEIMER, ERIK J. · 2018 to 2021
$1.4M
CIHR FDN-15427NIGMS NIH HHS R01 GM125797
6 · The paper itself

Abstract

Clustered regularly interspaced short palindromic repeats (CRISPR) together with their accompanying

Indexed as

ArchaeaBacteriaBacterial ProteinsBiological CoevolutionCRISPR-Associated ProteinsCRISPR-Cas SystemsDNADNA CleavageEndodeoxyribonucleasesGene EditingHumansModels, MolecularMultigene FamilyProtein BindingProtein MultimerizationRNA, Guide, CRISPR-Cas SystemsBacterial ProteinsCas12a proteinCRISPR-Associated ProteinsDNAEndodeoxyribonucleasesRNA, Guide, CRISPR-Cas SystemsSmall Molecule LibrariesViral ProteinsAcranti-CRISPRbacteriophageCRISPR-Casgenome editingmobile genetic element

Identifiers

PMID32186918
PMCPMC9718424
OpenAlexW3011435240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.