ArticleAmerican journal of respiratory and critical care medicine2020
Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease.
Open access · greenAbstract read
In one paragraph
Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 3 pooled it
9.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it, 85 citations in OpenAlex.
- Efficacy of vitamin D supplementation on COPD and asthma control: A systematic review and meta-analysis.Journal of global health · 2022Pooled it
- Vitamin D supplementation to treat SARS-CoV-2 positive patients. Evidence from meta-analysis.Cardiology journal · 2022Pooled it
- [Osteoporosis in pneumological diseases : Joint guideline of the Austrian Society for Bone and Mineral Research (ÖGKM) and the Austrian Society for Pneumology (ÖGP)].Wiener klinische Wochenschrift · 2021Guideline
- High-dose vitamin DNature communications · 2025Trial
- Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial.The American journal of clinical nutrition · 2022Trial
- Trial
- "Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study".The Journal of steroid biochemistry and molecular biology · 2020Trial
- Vitamin D as a cellular endocrine system: Tissue-specific microcircuits, immune reprogramming, and metabolic resistance.iScience · 2026Review
- Association Between SNAIL1 Gene Expression, SNAIL1 Genetic Variation, Vitamin D Receptor Gene Expression, and Vitamin-D Status Among Jordanian Asthmatic Patients.Journal of multidisciplinary healthcare · 2026Article
- Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette-Smoke Exposure.International forum of allergy & rhinology · 2025Article
- Nutritional insights into pulmonary fibrosis: a comprehensive review on the impact of vitamins.Frontiers in nutrition · 2025Review
- Chronic obstructive pulmonary disease: in-depth analysis of microbiota association and innovative prevention and treatment approaches from the gut-lung axis perspective.Frontiers in immunology · 2025Review
- Mechanisms of osteoporosis associated with chronic obstructive pulmonary disease.Journal of bone and mineral metabolism · 2024Review
- The production, function, and clinical applications of IL-33 in type 2 inflammation-related respiratory diseases.Frontiers in immunology · 2024Review
- Vitamin D supplementations and mortality among patients with moderate/severe COVID-19: A meta-analysis of randomized controlled trials.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024Review
- Genetic information supports a causal relationship between trace elements, inflammatory proteins, and COPD: evidence from a Mendelian randomization analysis.Frontiers in nutrition · 2024Article
- Vitamin B6 regulates IL-33 homeostasis to alleviate type 2 inflammation.Cellular & molecular immunology · 2023Article
- The role of diet and nutrition in the management of COPD.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Vitamin D status and chronic obstructive pulmonary disease risk: a prospective UK Biobank study.BMJ open respiratory research · 2023Article
- Calcifediol in the management of vitamin D deficiency-related skeletal and extraskeletal diseases: overview and clinical cases.Drugs in context · 2023Review
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 4 countries.
David A JolliffeAsthma UK Centre for Applied Research, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Christos StefanidisAsthma UK Centre for Applied Research, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Zhican WangDepartment of Pharmaceutics, University of Washington, Seattle, Washington.
Nazanin Z KermaniData Science Institute, William Penney Laboratory and.
Vassil DimitrovDepartment of Physiology, McGill University, Montreal, Quebec, Canada.
John H WhiteDepartment of Physiology, McGill University, Montreal, Quebec, Canada.
John E McDonoughYale School of Medicine, New Haven, Connecticut.
Wim JanssensLaboratory of Respiratory Diseases and Thoracic Surgery, Department of Chronic Diseases, Metabolism and Ageing, Katholieke Universiteit Leuven, Leuven, Belgium; and.
Paul PfefferAsthma UK Centre for Applied Research, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Christopher J GriffithsAsthma UK Centre for Applied Research, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Andrew BushNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.
Yike GuoData Science Institute, William Penney Laboratory and.
Stephanie ChristensonDivision of Pulmonary, Critical Care, Allergy, & Sleep Medicine, Department of Medicine, University of California, San Francisco, California.
Ian M AdcockNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.ORCID 0000-0003-2101-8843
Kian Fan ChungNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.
Kenneth E ThummelDepartment of Pharmaceutics, University of Washington, Seattle, Washington.
Adrian R MartineauAsthma UK Centre for Applied Research, Institute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.ORCID 0000-0001-5387-1721
Queen Mary University of London · GBImperial College London · GBMcGill University · CAUniversity of Washington · USKU Leuven · BEUniversity of California, San Francisco · USYale University · US
Funding
Hormonal Regulation of Human CYP3AR01GM063666 · NIGMS · UNIVERSITY OF WASHINGTON · PI THUMMEL, KENNETH E. · 2002 to 2017
$5.3MNIGMS NIH HHS R01 GM063666
Abstract
PubMed holds no abstract for this paper.
Indexed as
25-Hydroxyvitamin D3 1-alpha-HydroxylaseAsthmaCalcifediolCalcitriolCase-Control StudiesCholecalciferolCholestanetriol 26-MonooxygenaseCytochrome P-450 CYP3ACytochrome P450 Family 2FemaleHumansMaleMiddle AgedOxidoreductases Acting on CH-CH Group DonorsPolymorphism, Single NucleotidePulmonary Disease, Chronic Obstructive25-Hydroxyvitamin D3 1-alpha-Hydroxylase7-dehydrocholesterol reductaseCalcifediolCalcitriolCholecalciferolCholestanetriol 26-MonooxygenaseCYP24A1 protein, humanCYP27A1 protein, humanCYP27B1 protein, humanCYP2R1 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP3ACytochrome P450 Family 2GC protein, humanOxidoreductases Acting on CH-CH Group DonorsVitamin D3 24-HydroxylaseVitamin D-Binding ProteinVitamins1α,25-dihydroxyvitamin D24R,25-dihydroxyvitamin D4,β25-dihydroxyvitamin Dvitamin D 1α-hydroxylasevitamin D 25-hydroxylase
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.