Evidence map›Paper›PMID 32186399›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

cAMP signaling primes lung endothelial cells to activate caspase-1 during

Phoibe Renema, Kierra S Hardy, Nicole Housley, Grace Dunbar, Naga Annamdevula, Andrea Britain, Domenico Spadafora, Silas Leavesley, Thomas Rich, Jonathon P Audia and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Revealing the impact ofFrontiers in immunology · 2025
    Article
  3. Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD.European respiratory review : an official journal of the European Respiratory Society · 2022
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Phoibe RenemaDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.ORCID 0000-0003-0230-7068
Kierra S HardyDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
Nicole HousleyDepartment of Microbiology and Immunology, University of South Alabama, Mobile, Alabama.
Grace DunbarDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.
Naga AnnamdevulaDepartment of Pharmacology, University of South Alabama, Mobile, Alabama.
Andrea BritainDepartment of Pharmacology, University of South Alabama, Mobile, Alabama.
Domenico SpadaforaFlow Cytometry Core, University of South Alabama, Mobile, Alabama.
Silas LeavesleyDepartment of Chemical and Biomolecular Engineering, University of South Alabama, Mobile, Alabama.
Thomas RichDepartment of Pharmacology, University of South Alabama, Mobile, Alabama.
Jonathon P AudiaDepartment of Microbiology and Immunology, University of South Alabama, Mobile, Alabama.
Diego F AlvarezDepartment of Physiology and Cell Biology, University of South Alabama, Mobile, Alabama.ORCID 0000-0001-8244-629X
University of South Alabama · US

Funding

T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LEAVESLEY, SILAS JOSIAH · 2001 to 2022
$34.6M
Caspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0M
Request for a Spectral Confocal MicroscopeS10RR027535 · NCRR · UNIVERSITY OF SOUTH ALABAMA · PI RICH, THOMAS C · 2010 to 2010
$397k
NCRR NIH HHS S10 RR027535NHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL118334
6 · The paper itself

Abstract

Activation of the inflammasome-caspase-1 axis in lung endothelial cells is emerging as a novel arm of the innate immune response to pneumonia and sepsis caused by

Indexed as

Signal Transduction1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAdenineAlprostadilAnimalsCaspase 1Cell ProliferationColforsinCyclic AMPCyclic GMPDinoprostoneEndothelial CellsGene Expression RegulationHost-Pathogen InteractionsInflammasomes1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine Monophosphate8-bromocyclic GMP9-(tetrahydro-2-furyl)-adenineAdenineAlprostadilbutaprostCaspase 1ColforsinCyclic AMPCyclic GMPDinoprostoneIL1B protein, ratInflammasomesInterleukin-1betaRolipramcAMPcaspase-1Pseudomonas aeruginosapulmonary endothelial cellsstress responses

Identifiers

PMID32186399
PMCPMC7272745
OpenAlexW3011127308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.