Evidence map›Paper›PMID 32186246›Full record

Trial reportTherapeutic advances in cardiovascular disease

Multicap to improve adherence after acute coronary syndromes: results of a randomized controlled clinical trial.

Javier Mariani, Andrés Rosende, Maximiliano De Abreu, Gabriel Gonzalez Villa Monte, Heraldo D'Imperio, Laura Antonietti, Gabriela Lemonnier, Alejandra de Bonis, Carlos Tajer

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Therapeutic advances in cardiovascular disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02271178 (Multi-cap for Increase Adherence After Acute Myocardial Infarction), which is not on this map. Cited by 10 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 6 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02271178 phase3terminatednot on this map

Multi-cap for Increase Adherence After Acute Myocardial Infarction

TypeinterventionalSponsorHospital El CruceRan2014 to 2016Enrolled100ConditionsMyocardial InfarctionArmsCombined capsule, Conventional therapy
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 6 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Javier MarianiCardiology Department, Hospital El Cruce, Avenida Calchaquí 5401, Florencio Varela, Buenos Aires, CP 1888, Argentina.ORCID https://orcid.org/0000-0002-9372-6817
Andrés RosendeCardiology Department, Hospital El Cruce, Florencio Varela, Buenos Aires, Argentina.
Maximiliano De AbreuCardiology Department, Hospital El Cruce, Florencio Varela, Buenos Aires, Argentina.
Gabriel Gonzalez Villa MonteHospital El Cruce, Florencio Varela, Buenos Aires, Argentina.
Heraldo D'ImperioCardiology Department, Hospital El Cruce, Florencio Varela, Buenos Aires, Argentina.
Laura AntoniettiCardiology Department, Hospital El Cruce, Florencio Varela, Buenos Aires, Argentina.ORCID https://orcid.org/0000-0002-7676-4264
Gabriela LemonnierPharmacy Department, Hospital El Cruce, Florencio Varela, Buenos Aires, Argentina.
Alejandra de BonisHemotherapy Department, Hospital El Cruce, Florencio Varela, Buenos Aires, Argentina.
Carlos TajerCardiology Department, Hospital El Cruce, Florencio Varela, Buenos Aires, Argentina.
Hospital El Cruce · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdherence to treatment after a myocardial infarction (MI) is poor, even in the early postinfarction period. Combining evidence-based drugs into a multicap could improve adherence in this population. No previous randomized trial assessing fixed-dose combination therapy has included patients early after a MI. We aimed to assess if a multicap containing four secondary prevention drugs increases adherence to treatment at 6 months after MI hospitalization. The study was designed as a randomized, parallel, open-label, controlled trial.

methodsPatients were randomized within 7 days of a MI to either multicap or control group. The multicap group received a capsule containing aspirin, atenolol, ramipril, and simvastatin. The control group received each drug in separate pills. The primary outcome was adherence at 6 months. We also measured blood pressure, heart rate, serum cholesterol levels, C-reactive protein, and platelet aggregation.

resultsThe study was stopped prematurely when 100 patients were included for futility. At 6 months, 92 (95.8%) patients were adherent to medical treatment: 98.0% in the multicap group and 93.5% in the control group [relative risk (RR) 1.05; 95% confidence interval (CI) 0.96-1.14;

conclusionsThe study did not find any improvement in the adherence at 6 months after a MI with a multicap-based strategy (Multicap for Increase Adherence After Acute Myocardial Infarction; [ ClinicalTrials.gov identifier: NCT02271178]).

Indexed as

Medication AdherenceAcute Coronary SyndromeAdministration, OralAdrenergic beta-1 Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsArgentinaAspirinAtenololDrug CombinationsFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsAdrenergic beta-1 Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAspirinAtenololDrug CombinationsHydroxymethylglutaryl-CoA Reductase InhibitorsPlatelet Aggregation InhibitorsRamiprilSimvastatinTabletscoronary heart diseasefixed-dose combination therapymulticapmyocardial infarctionpolypillsecondary prevention

Identifiers

PMID32186246
PMCPMC7081461
OpenAlexW3010935656

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.