ArticleJournal of cosmetic dermatology2020
Managing intravascular complications following treatment with calcium hydroxylapatite: An expert consensus.
Article in Journal of cosmetic dermatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Autologous Fat Grafting Versus Facial Fillers in Facial Cosmesis: A Systematic review and Meta-analysis.Aesthetic plastic surgery · 2026Pooled it
- Visual Loss in Biostimulator Injectables: A Review of Incidence, Risk Factors, Etiology and Management Proposal.Aesthetic plastic surgery · 2026Pooled it
- Foreign Body Granulomas Reaction Related to Collagen Stimulatory Cosmetic Fillers: A Systematic Review.Journal of cosmetic dermatology · 2025Pooled it
- Diluted and Hyperdiluted Calcium Hydroxylapatite/Carboxymethylcellulose as a Technique Platform: A Narrative Review with Practical Taxonomy, Injection Mapping, and Safety.Aesthetic plastic surgery · 2026Review
- Micropuncture Decompression With High-Dose Hyaluronidase for Early Reversal of Nasal Ischaemia from HA-Biostimulator Mixed Fillers: An Illustrative Case and Technical Algorithm.Aesthetic plastic surgery · 2026Article
- Hyaluronic Acid Dermal Filler-Associated Vascular Occlusion-A Review of Prevention and Management Strategies.Journal of cosmetic dermatology · 2026Review
- Hyperbaric Oxygen Therapy in the Management of Dermal Filler-Induced Vascular Occlusion: A Scoping Review.The Journal of clinical and aesthetic dermatology · 2026Review
- Cannula is safer than needle in filler injection?JPRAS open · 2026Review
- Staged Management of Vascular Occlusion With Ellansé (Polycaprolactone): A Modified Delphi Expert Consensus.Aesthetic surgery journal. Open forum · 2026Article
- When Labiaplasty is Not Enough: Rejuvenation of the Labia Majora Using Hybrid Calcium Hydroxylapatite With Hyaluronic Acid Filler for Increased Satisfaction and Uniform Results.Aesthetic surgery journal. Open forum · 2026Article
- Large vessel ischemic stroke secondary to filler injection into the internal carotid artery at a medical spa: A devastating complication.JAAD case reports · 2025Article
- Arterioembolic Characteristics of Differentially Diluted CaHA-CMC Gels Within An Artificial Macrovascular Perfusion Model.Aesthetic surgery journal · 2025Article
- Proposing a New Classification for Managing Prostaglandin-Induced Enophthalmos in Glaucoma Patients.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Precise Needle and Cannula Placement in the Forehead During Aesthetic Procedures: Can Device and Angulation Influence Accuracy? A Fresh Frozen Specimen Study.Aesthetic plastic surgery · 2025Article
- Prevention and Management of Complications With a Hyaluronic Acid-Calcium Hydroxyapatite Hybrid Injectable.Clinical, cosmetic and investigational dermatology · 2025Review
- Safe Zones for Facial Fillers: Anatomical Study of SubSMAS Spaces in Asians.Diagnostics (Basel, Switzerland) · 2024Article
- Anatomy of the temporal region to guide filler injections.Surgical and radiologic anatomy : SRA · 2024Review
- Laser Speckle Contrast Imaging Guides Needling Treatment of Vascular Complications from Dermal Fillers.Aesthetic plastic surgery · 2024Article
- Resolution of Vascular Compromise From Liquid Rhinoplasty UsingAesthetic surgery journal. Open forum · 2024Article
- Concentrated Growth Factor (CGF): The Newest Platelet Concentrate and Its Application in Nasal Hyaluronic Acid Injection Complications.Aesthetic plastic surgery · 2023Article
Corrections and comments
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Authors and funding
17 authors at 13 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInadvertent intra-arterial injection of dermal fillers including calcium hydroxylapatite (CaHA) can result in serious adverse events including soft tissue necrosis, permanent scarring, visual impairment, and blindness. When intra-arterial injection occurs, immediate action is required for optimal outcomes, but the infrequency of this event means that many physicians may never have experienced this scenario. The aim of this document is to provide evidence-based and expert opinion recommendations for the recognition and management of vascular compromise following inadvertent injection of CaHA.
methodsAn international group of experts with experience in injection of CaHA and management of vascular complications was convened to develop a consensus on the optimal management of vascular compromise following intra-arterial CaHA injection. The consensus members were asked to provide preventative advice for the avoidance of intravascular injection and to produce a treatment protocol for acute and delayed presentation. To ensure all relevant treatment options were included, the recommendations were supplemented with a PubMed search of the literature.
resultsFor prevention of intra-arterial CaHA injection, consensus members outlined the importance of a thorough knowledge of facial vascular anatomy and patient history, as well as highlighting potential risk zones and optimal injection techniques. Individual sections document how to recognize the symptoms of vascular occlusion leading to vision loss and tissue necrosis as well as detailed treatment protocols for the management of these events. For impending tissue necrosis, recommendations are provided for early and delayed presentations with treatment protocols for acute and follow-up treatment. A separate section details the treatment options for open and closed wounds.
conclusionsAll physicians should be prepared for the eventuality of intra-arterial injection of a dermal filler, despite its rarity. These consensus recommendations combine advice from aesthetic experts with the latest reports from the published literature to provide an up-to-date office-based protocol for the prevention and treatment of complications arising from intra-arterial CaHA injection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.