ReviewMolecular microbiology2020
Selective and non-selective bottlenecks as drivers of the evolution of hypermutable bacterial loci.
Review in Molecular microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Codon bias variation in Staphylococcus aureus.PloS one · 2026Article
- A 5'-UTR cis-acting RNA element targeted by RNase III is essential for DNA simple sequence repeat-dependent phase variation in Haemophilus influenzae.Nucleic acids research · 2025Article
- Evolutionary dynamics of nascent multicellular lineages.Proceedings. Biological sciences · 2025Article
- Genetic Characterization and Zoonotic Potential ofTropical medicine and infectious disease · 2025Article
- 100+ years of phase variation: the premier bacterial bet-hedging phenomenon.Microbiology (Reading, England) · 2025Review
- Aging through the lens of mitochondrial DNA mutations and inheritance paradoxes.Biogerontology · 2024Review
- Advantage of an epigenetic switch in response to alternate environments.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Microbial Primer: Phase variation - survival and adaptability by generation of a diverse population.Microbiology (Reading, England) · 2024Review
- Mutation bias and adaptation in bacteria.Microbiology (Reading, England) · 2023Review
- Promotion of plasmid maintenance by heterogeneous partitioning of microbial communities.Cell systems · 2023Article
- A Selective Bottleneck During Host Entry Drives the Evolution of New Legume Symbionts.Molecular biology and evolution · 2023Article
- The Host-Pathogen Interactions and Epicellular Lifestyle ofFrontiers in cellular and infection microbiology · 2022Review
- Evolutionary Pathways and Trajectories in Antibiotic Resistance.Clinical microbiology reviews · 2021Article
- Modelling evolutionary pathways for commensalism and hypervirulence inMicrobial genomics · 2021Article
- Selective and non-selective bottlenecks as drivers of the evolution of hypermutable bacterial loci.Molecular microbiology · 2020Review
- Pathogenic Differences of Type 1 Restriction-Modification Allele Variants in ExperimentalFrontiers in cellular and infection microbiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Bottlenecks reduce the size of the gene pool within populations of all life forms with implications for their subsequent survival. Here, we examine the effects of bottlenecks on bacterial commensal-pathogens during transmission between, and dissemination within, hosts. By reducing genetic diversity, bottlenecks may alter individual or population-wide adaptive potential. A diverse range of hypermutable mechanisms have evolved in infectious agents that allow for rapid generation of genetic diversity in specific genomic loci as opposed to the variability arising from increased genome-wide mutation rates. These localised hypermutable mechanisms include multi-gene phase variation (PV) of outer membrane components, multi-allele PV of restriction systems and recombination-driven antigenic variation. We review selected experimental and theoretical (mathematical) models pertaining to the hypothesis that localised hypermutation (LH) compensates for fitness losses caused by bottlenecks and discuss whether bottlenecks have driven the evolution of hypermutable loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.