Evidence map›Paper›PMID 32185796›Full record

ArticleInternational dental journal2020

The relationship between the anti-Porphyromonas gingivalis immunoglobulin G subclass antibody and small for gestational age delivery: a longitudinal study in pregnant Japanese women.

Changchang Ye, Hiroaki Kobayashi, Sayaka Katagiri, Naoyuki Miyasaka, Yasuo Takeuchi, Ryutaro Kuraji, Yuichi Izumi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International dental journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Oral microbiome and preterm birth.Frontiers in medicine · 2023
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Changchang YeState Key Laboratory of Oral Diseases, Department of Periodontology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0003-4713-0809
Hiroaki KobayashiDepartment of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan.ORCID https://orcid.org/0000-0001-9481-5013
Sayaka KatagiriDepartment of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan.ORCID https://orcid.org/0000-0002-5765-2742
Naoyuki MiyasakaDepartment of Pediatrics, Perinatal and Maternal Medicine, Tokyo Medical and Dental University Medical Hospital, Tokyo, Japan.
Yasuo TakeuchiDepartment of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan.ORCID https://orcid.org/0000-0003-4193-219X
Ryutaro KurajiDepartment of Life Science Dentistry and Department of Periodontology, The Nippon Dental University School of Life Dentistry at Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0002-7900-3604
Yuichi IzumiDepartment of Periodontology, Tokyo Medical and Dental University, Tokyo, Japan.
Tokyo Medical and Dental University · JPNippon Dental University · JPSichuan University · CNTokyo Medical and Dental University Hospital · JP

Funding

Chengdu Science and Technology Bureau 2015-HM01-00088-SFJapan Society for the Promotion of Science 16K11826National Natural Science Foundation of China 81600875
6 · The paper itself

Abstract

backgroundMaternal serum IgG antibody against Porphyromonas gingivalis is an indicator of both periodontitis and adverse pregnancy outcomes. This study aims to evaluate the anti-P. gingivalis IgG and IgG subclasses1-4 in threatened preterm labour (TPL) patients and their association with small for gestational age (SGA).

methodsSerum, saliva and subgingival plaque samples were collected from 47 TPL patients compared with 48 healthy pregnant women. The amount of P. gingivalis was measured in saliva and plaque using real-time polymerase chain reaction. The serum anti-P. gingivalis IgG titre and anti-P. gingivalis subclasses IgG 1-4 concentration were measured using enzyme-linked immunosorbent assay.

resultsThe amount of anti-P. gingivalis IgG-1 was significantly lower in the TPL group than in the healthy group. Fourteen subjects delivered SGA infants in the TPL group. The pocket probing depth (PPD), clinical attachment loss, PPD ≥ 5 mm%, amount of P. gingivalis in plaque, anti-P. gingivalis IgG and anti-P. gingivalis IgG-4 were significantly higher in the TPL-SGA group than in the TPL-normal weight group. Moreover, logistic regression analysis revealed the detection frequency of P. gingivalis in plaque and placenta weight were significantly correlated with SGA in TPL. In the receiver operating characteristic curve analysis, an amount of P. gingivalis in plaque ≥ 86.45 copies showed a sensitivity of 0.786 and a specificity of 0.727 (AUC 0.792) for predicting SGA in TPL.

conclusionLower anti-P. gingivalis IgG-1 amounts are related to TPL, while higher anti-P. gingivalis IgG and IgG-4 are related with SGA in TPL. Further, greater colonisation of P. gingivalis in plaque might increase the risk of SGA and can be useful in prediction of SGA in TPL.

Indexed as

Immunoglobulin GPorphyromonas gingivalisFemaleGestational AgeHumansInfantInfant, NewbornJapanLongitudinal StudiesPregnancyImmunoglobulin Gimmunoglobulin G subclasses antibodyPorphyromonas gingivalissmall for gestational agethreatened preterm labour

Identifiers

PMID32185796
PMCPMC9379198
OpenAlexW3012560681

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.