Evidence map›Paper›PMID 32185687›Full record

ArticleMolecular biology reports2020

Conversion of human urine-derived cells into neuron-like cells by small molecules.

Donghui Liu, Grigori Rychkov, Mohammed Al-Hawwas, Nimshitha Pavathuparambil Abdul Manaph, Fiona Zhou, Larisa Bobrovskaya, Hong Liao, Xin-Fu Zhou

Abstract read
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In one paragraph

Article in Molecular biology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Donghui LiuSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Grigori RychkovDiscipline of Medicine, School of Medicine, University of Adelaide, Adelaide, SA, 5000, Australia.
Mohammed Al-HawwasSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Nimshitha Pavathuparambil Abdul ManaphNeurological Disorders Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Fiona ZhouSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Larisa BobrovskayaSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5000, Australia.
Hong LiaoJiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, 24 Tongjiaxiang Street, Nanjing, 210009, China. hliao@cpu.edu.cn.
Xin-Fu ZhouSchool of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, 5000, Australia. xin-fu.zhou@unisa.edu.au.
University of South Australia · AUChina Pharmaceutical University · CNHamad bin Khalifa University · QASouth Australian Health and Medical Research Institute · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural cell transplantation is an effective way for treatment of neurological diseases. However, the absence of transplantable human neurons remains a barrier for clinical therapies. Human urine-derived cells, namely renal cells and urine stem cells, have become a good source of cells for reprogramming or trans-differentiation research. Here, we show that human urine-derived cells can be partially converted into neuron-like cells by applying a cocktail of small molecules. Gene expression analysis has shown that these induced cells expressed some neuron-specific genes, and a proportion of the cells are GABAergic neurons. Moreover, whole-cell patch clamping recording has shown that some induced cells have neuron-specific voltage gated Na

Indexed as

Action PotentialsAdultCell Culture TechniquesCell DifferentiationCells, CulturedHumansInduced Pluripotent Stem CellsMaleMiddle AgedNeural Stem CellsNeuronsPatch-Clamp TechniquesUrineInduced neuronal cellsSmall moleculesStem cellsTrans-differentiationUrine-derived cells

Identifiers

PMID32185687
OpenAlexW3011666419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.