Evidence map›Paper›PMID 32185608›Full record

ArticleIn vitro cellular & developmental biology. Animal2020

Eldecalcitol (ED-71)-induced exosomal miR-6887-5p suppresses squamous cell carcinoma cell growth by targeting heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1).

M Higaki, T Shintani, A Hamada, S N Z Rosli, T Okamoto

Abstract read
PubMed Publisher
In one paragraph

Article in In vitro cellular & developmental biology. Animal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Emerging roles of exosomes in oral diseases progression.International journal of oral science · 2024
    Review
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Inhibition of vitamin D analog eldecalcitol on hepatomaOpen medicine (Warsaw, Poland) · 2020
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M HigakiOral Maxillofacial Surgery, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.
T ShintaniCenter of Oral Clinical Examination, Hiroshima University Hospital, Hiroshima, 734-8553, Japan. tshintan@hiroshima-u.ac.jp.
A HamadaOral Maxillofacial Surgery, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.
S N Z RosliDepartment of Molecular Oral Medicine and Maxillofacial Surgery, Division of Dentistry, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, 734-8553, Japan.
T OkamotoOral Maxillofacial Surgery, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.
Hiroshima University Hospital · JPHiroshima University · JP

Funding

Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology 15H05043Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology 16K11723
6 · The paper itself

Abstract

Heparin-binding protein 17/fibroblast growth factor-binding protein-1 (HBp17/FGFBP-1) was purified from A431 cell-conditioned media based on its capacity to bind to fibroblast growth factor 1 and 2 (FGF-1 and FGF-2). HBp17/FGFBP-1 has been observed to induce the tumorigenic potential of epithelial cells and is highly expressed in oral cancer cell lines and tissues. HBp17/FGFBP-1 is also recognized as a pro-angiogenic molecule as a consequence of its interaction with FGF-2. We have previously reported that Eldecalcitol (ED-71), an analog of 1α,25(OH)

Indexed as

AnimalsBase SequenceCarcinoma, Squamous CellCell Line, TumorCell ProliferationCulture Media, ConditionedExosomesIntercellular Signaling Peptides and ProteinsMaleMice, Inbred BALB CMice, NudeMicroRNAsMouth NeoplasmsUp-RegulationVitamin DCulture Media, ConditionedeldecalcitolFGFBP1 protein, humanIntercellular Signaling Peptides and ProteinsMicroRNAsVitamin DEldecalcitol (ED-71)ExosomeHBp17/FGFBP-1miR-6887-5pOral squamous cell carcinoma

Identifiers

PMID32185608
OpenAlexW3012230415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.