Evidence map›Paper›PMID 32185596›Full record

ArticleAIDS and behavior2020

Sex Work as a Mediator Between Female Gender and Incident HIV Infection Among People Who Inject Drugs in Tijuana, Mexico.

Jennifer P Jain, Daniela Abramovitz, Steffanie A Strathdee, Patricia Gonzalez-Zuniga, Gudelia Rangel, Brooke S West, Eileen V Pitpitan

Abstract read
In one paragraph

Article in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. HIV and Substance Use in Latin America: A Scoping Review.International journal of environmental research and public health · 2022
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jennifer P JainSchool of Medicine, University of California, San Diego, La Jolla, USA. Jennifer.Jain@ucsf.edu.
Daniela AbramovitzSchool of Medicine, University of California, San Diego, La Jolla, USA.
Steffanie A StrathdeeSchool of Medicine, University of California, San Diego, La Jolla, USA.
Patricia Gonzalez-ZunigaSchool of Medicine, University of California, San Diego, La Jolla, USA.
Gudelia RangelUnited States-Mexico Border Health Commission and El Colegio de la Frontera Norte, Tijuana, Mexico.
Brooke S WestSchool of Social Work, Columbia University, New York, United States.
Eileen V PitpitanSchool of Medicine, University of California, San Diego, La Jolla, USA.

Funding

Training Program in Substance Use, HIV and Related InfectionsT32DA023356 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Natasha Martin, Steffanie A Strathdee · 2007 to 2026
$7.8M
Impact of Drug Policy Reform on the HIV Risk Environment among IDUs in TijuanaR37DA019829 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STRATHDEE, STEFFANIE A. · 2010 to 2019
$6.7M
Drug tourism to Mexico: Impact of Mexicos new drug law on HIV-HCV-TB in US IDUsR01DA031074 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARFEIN, RICHARD S · 2011 to 2015
$3.2M
Estimating Mediation and Moderation Effects in HIV Incidence Prevention TrialsR01DA042666 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PITPITAN, EILEEN VIRTUSIO · 2018 to 2022
$2.6M
NIDA NIH HHS R01DA031074NIDA NIH HHS R01 DA042666NIDA NIH HHS R37DA019829NIDA NIH HHS T32 DA023356NIDA NIH HHS T32 DA 23356-11
6 · The paper itself

Abstract

We studied mechanisms driving gender differences in HIV incidence among 651 women and men who inject drugs (PWID) in Tijuana, Mexico, hypothesizing that sex work will mediate the association between female gender and HIV incidence. Of 43 HIV seroconversions occurring between 2011 and 2018, 8.8% were among females and 5.2% among males. HIV incidence density was significantly higher among females versus males (1.75 per 100 person years [PY], 95% CI 1.16-2.66, vs. 0.95 per 100 PY, 95% CI 0.62-1.47). Factors significantly associated with HIV seroconversion were: sex work (adjusted hazard ratio [aHR] = 2.25, 95% CI 1.05-4.80); methamphetamine injection (aHR = 2.30, 95% CI 1.12-4.73); and methamphetamine and heroin co-injection in the past six months (aHR = 2.26, 95% CI 1.23-4.15). In mediation analyses, sex work mediated a substantial proportion (84.3%) of the association between female gender and HIV incidence. Interventions should target female PWID who engage in sex work to reduce gender-related disparities in HIV incidence.

Indexed as

Sex WorkAdultFemaleHeroinHIV InfectionsHumansIncidenceMaleMethamphetamineMexicoMiddle AgedRisk FactorsSubstance Abuse, IntravenousSurveys and QuestionnairesHeroinMethamphetamineHIV incidenceMediationMexicoPeople who inject drugsSex work

Identifiers

PMID32185596
PMCPMC7453791

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.