ArticleClinical research in cardiology : official journal of the German Cardiac Society2020
Recurrent infective endocarditis versus first-time infective endocarditis after heart valve surgery.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Trial
- Risk Factors Associated With Positive Intraoperative Valve Tissue Cultures and the Subsequent Impact on Infective Endocarditis Management and Outcomes.Open forum infectious diseases · 2026Article
- Low Yield of Blood Cultures After End of Therapy of an Episode of Infective Endocarditis: 12 Years' Experience From a Referral Center.Open forum infectious diseases · 2026Article
- Recurrences of the infective endocarditis: clinical features and outcomes. Results from the Polish infective endocarditis registry (POL-ENDO).International journal of cardiology. Heart & vasculature · 2025Article
- Review
- Surgery in patients with infective endocarditis and prognostic importance of patient frailty.Infection · 2024Article
- Survival and Recurrence of Endocarditis following Mechanical vs. Biological Aortic Valve Replacement for Endocarditis in Patients Aged 40 to 65 Years: Data from the INFECT-Registry.Journal of clinical medicine · 2023Article
- The diagnostic benefit of 16S rDNA PCR examination of infective endocarditis heart valves: a cohort study of 146 surgical cases confirmed by histopathology.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Observational
- Incidence of infective endocarditis during the coronavirus disease 2019 pandemic: A nationwide study.International journal of cardiology. Heart & vasculature · 2020Article
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10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInfective endocarditis (IE) may require heart valve surgery. It is well known that heart valve surgery itself and previous IE predispose to IE. However, data are sparse on whether the risk of IE is different among patients undergoing valve surgery due to IE and other causes (i.e. recurrent vs. first-time IE).
methodsUsing Danish nationwide registries, patients undergoing left-sided heart valve surgery in the course of an IE hospitalization (1996-2017) were identified and matched with controls undergoing left-sided heart valve surgery due to another cause than IE in a 1:1 ratio. Patients were stratified according to type of surgical valve intervention and affected valve. The comparative risk of recurrent vs. first-time IE was assessed by cumulative incidence curves and multivariable Cox regression analyses.
resultsThe study population comprised 971 patients with a first-time admission for IE requiring heart valve surgery matched with 971 controls undergoing heart valve surgery due to other causes than IE. The risk of recurrent IE was significantly higher than the risk of first-time IE following heart valve surgery (5.5% and 3.0% by 10 years, hazard ratio (HR) 1.66, 95% confidence interval (CI) 1.02-2.70). The risk of IE recurrence was not significantly different comparing valve replacement and valve repair (5.5% and 5.3%, respectively, HR 1.60, 95% CI 0.71-3.60). Yet, the risk of IE recurrence was significantly higher among patients with biological versus mechanical prostheses (6.3% and 4.6%, respectively, HR 2.00, 95% CI 1.02-3.70).
conclusionsFollowing heart valve surgery, the risk of recurrent IE was significantly higher than the risk of first-time IE.
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