Evidence map›Paper›PMID 32185416›Full record

ArticleArchives of toxicology2020

Cellular levels and molecular dynamics simulations of estragole DNA adducts point at inefficient repair resulting from limited distortion of the double-stranded DNA helix.

Shuo Yang, Matthias Diem, Jakob D H Liu, Sebastiaan Wesseling, Jacques Vervoort, Chris Oostenbrink, Ivonne M C M Rietjens

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Shuo YangDivision of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. shuo.yang@wur.nl.ORCID http://orcid.org/0000-0003-2755-7573
Matthias DiemDepartment of Material Sciences and Process Engineering, Institute of Molecular Modeling and Simulation, University of Natural Resources and Life Science, Vienna, Austria.ORCID https://orcid.org/0000-0002-7428-6430
Jakob D H LiuDepartment of Material Sciences and Process Engineering, Institute of Molecular Modeling and Simulation, University of Natural Resources and Life Science, Vienna, Austria.ORCID https://orcid.org/0000-0002-9591-4803
Sebastiaan WesselingDivision of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Jacques VervoortDivision of Biochemistry, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Chris OostenbrinkDepartment of Material Sciences and Process Engineering, Institute of Molecular Modeling and Simulation, University of Natural Resources and Life Science, Vienna, Austria.ORCID https://orcid.org/0000-0002-4232-2556
Ivonne M C M RietjensDivision of Toxicology, Wageningen University, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Wageningen University & Research · NLBOKU University · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estragole, naturally occurring in a variety of herbs and spices, can form DNA adducts after bioactivation. Estragole DNA adduct formation and repair was studied in in vitro liver cell models, and a molecular dynamics simulation was used to investigate the conformation dependent (in)efficiency of N

Indexed as

Allylbenzene DerivativesAnimalsAnisolesCarcinogensChromatography, LiquidCricetinaeCricetulusDeoxyguanosineDNADNA AdductsDNA RepairFlavoring AgentsHepatocytesMass SpectrometryMolecular Dynamics SimulationRats1'-hydroxyestragoleAllylbenzene DerivativesAnisolesCarcinogensDeoxyguanosineDNADNA AdductsestragoleFlavoring AgentsDNA adductDNA repair efficiencyEstragoleMolecular modeling and simulation

Identifiers

PMID32185416
PMCPMC7225201
OpenAlexW3011386392

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.