ArticleMediterranean journal of rheumatology2019
Association between Takayasu arteritis and ischemic heart disease: a cohort study.
Article in Mediterranean journal of rheumatology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 11 citations in OpenAlex.
- Acute Coronary Syndrome in a Young Woman With Takayasu Arteritis and Pancoronary Aneurysms.JACC. Case reports · 2025Article
- Coronary artery lesions in Takayasu arteritis.Reumatologia · 2023Review
- The clinical features of pulmonary artery involvement in Takayasu arteritis and its relationship with ischemic heart diseases and infection.Arthritis research & therapy · 2021Article
- Electrical storm in a patient with Takayasu arteritis and inferior myocardial scar.HeartRhythm case reports · 2021Article
- A Case Report: An Elderly Male Patient With Takayasu Arteritis After Coronary Artery Bypass Grafting.Frontiers in cardiovascular medicine · 2021Article
- Mediterranean Journal of Rheumatology September 2019 Issue Highlights.Mediterranean journal of rheumatology · 2019Article
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of the studyTakayasu arteritis (TA) is an idiopathic large vessel vasculitis, which involves the aorta and its major branches. Our aim was to examine the association between TA and the development of ischemic heart disease (IHD) and its impact on survival. STUDY
designUsing data from Clalit Health Services (CHS), the largest Health Maintenance Organization (HMO) in Israel, the proportion of IHD was compared between patients diagnosed with TA and age- and gender-matched controls. Chi-square and t-tests were used for univariate analysis, and a logistic regression model was employed for multivariate analysis. Survival analysis was performed using Kaplan-Meier plots and cox regression.
resultsThe study included 155 TA patients and 755 age- and gender-frequency matched controls. The proportion of IHD in TA patients was increased in comparison with controls (32.3% and 8.9%, p<0.001). In multivariate analysis, IHD was associated with TA (OR=6.576, 95% CI: 4.09-10.64) and male gender (OR=2.29, 95% CI: 1.43-4.26). Survival analysis over 15 years of follow-up showed a higher proportion of all-causes mortality in the TA group. In a multivariate analysis, TA (HR=2.58, 95%CI: 1.64-4.06) and IHD (HR=1.64, 95%CI: 1.05-2.55) were found to be associated with reduced survival.
conclusionsTA patients present an increased proportion of IHD, and a reduced 15-years survival rate compared to controls.
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