Evidence map›Paper›PMID 32185240›Full record

ArticleNeurology. Genetics2020

Heritability of cervical spinal cord structure.

Linda Solstrand Dahlberg, Olivia Viessmann, Clas Linnman

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Charting Cervical Spinal Cord Morphometry Across the Lifespan.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Biological variation in cervical spinal cord MRI morphometry in healthy individuals and people with multiple sclerosis.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Linda Solstrand DahlbergDepartment of Anesthesiology, Perioperative and Pain Medicine (L.S.D., C.L.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Psychiatry and Radiology (L.S.D., C.L.), Massachusetts General Hospital, Harvard Medical School; Department of Neurology and Neurosurgery (L.S.D.), Montreal Neurological Institute, McGill University, Canada; Athinoula A. Martinos Center for Biomedical Imaging (O.V.), Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Boston; and Spaulding Neuroimaging Lab (C.L.), Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA.
Olivia ViessmannDepartment of Anesthesiology, Perioperative and Pain Medicine (L.S.D., C.L.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Psychiatry and Radiology (L.S.D., C.L.), Massachusetts General Hospital, Harvard Medical School; Department of Neurology and Neurosurgery (L.S.D.), Montreal Neurological Institute, McGill University, Canada; Athinoula A. Martinos Center for Biomedical Imaging (O.V.), Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Boston; and Spaulding Neuroimaging Lab (C.L.), Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA.
Clas LinnmanDepartment of Anesthesiology, Perioperative and Pain Medicine (L.S.D., C.L.), Boston Children's Hospital, Harvard Medical School, MA; Departments of Psychiatry and Radiology (L.S.D., C.L.), Massachusetts General Hospital, Harvard Medical School; Department of Neurology and Neurosurgery (L.S.D.), Montreal Neurological Institute, McGill University, Canada; Athinoula A. Martinos Center for Biomedical Imaging (O.V.), Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, Boston; and Spaulding Neuroimaging Lab (C.L.), Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA.
Harvard University · USMassachusetts General Hospital · USMcGill University · CA

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
Improving Human fMRI through Modeling and Imaging Microvascular Dynamics: Administrative SupplementR01MH111419 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI POLIMENI, JONATHAN RIZZO · 2016 to 2020
$4.9M
An exercise intervention to Reduce Neuropathic Pain and Brain Inflammation after Spinal Cord InjuryR01HD097407 · NICHD · SPAULDING REHABILITATION HOSPITAL · PI LINNMAN, CLAS · 2019 to 2023
$2.7M
NIBIB NIH HHS P41 EB027061NICHD NIH HHS R01 HD097407NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

objectiveMeasures of spinal cord structure can be a useful phenotype to track disease severity and development; this observational study measures the hereditability of cervical spinal cord anatomy and its correlates in healthy human beings.

methodsTwin data from the Human Connectome Project were analyzed with semiautomated spinal cord segmentation, evaluating test-retest reliability and broad-sense heritability with an AE model. Relationships between spinal cord metrics, general physical measures, regional brain structural measures, and motor function were assessed.

resultsWe found that the spinal cord C2 cross-sectional area (CSA), left-right width (LRW), and anterior-posterior width (APW) are highly heritable (85%-91%). All measures were highly correlated with the brain volume, and CSA only was positively correlated with thalamic volumes (

conclusionsThis study provides the evidence of genetic influence on spinal cord structure. MRI metrics of cervical spinal cord anatomy are robust and not easily influenced by nonpathological environmental factors, providing a useful metric for monitoring normal development and progression of neurodegenerative disorders affecting the spinal cord, including-but not limited to-spinal cord injury and MS.

Identifiers

PMID32185240
PMCPMC7061306
OpenAlexW3008072777

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.