Evidence map›Paper›PMID 32185238›Full record

ArticleJournal of immunology research2020

Haplotype Analysis of Candidate Genes Involved in Inflammation and Oxidative Stress and the Susceptibility to Preeclampsia.

Aiping Chen, Huifang Zhao, Jingli Wang, Ru Zhang, Jingjing Liu, Xin Zhao, Congying Li, Xuewen Jia, Xueying Li, Yan Lin and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. The Role of rs713041 Glutathione Peroxidase 4 (International journal of molecular sciences · 2022
    Pooled it
  2. T174M-M235TCurrent issues in molecular biology · 2026
    Article
  3. Review
  4. Article
  5. BMA-based Mendelian randomization identifies blood metabolites as causal candidates in pregnancy-induced hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. The effects ofMolecular biology research communications · 2024
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Aiping ChenDepartment of Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Huifang ZhaoSchool of Nursing, Weifang University of Science and Technology, Shouguang, China.
Jingli WangMedical Genetic Department, Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Ru ZhangMedical Genetic Department, Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, China.
Jingjing LiuDepartment of Laboratory, Qingdao Municipal Hospital, Qingdao, China.
Xin ZhaoDepartment of Gynecology and Obstetrics, Qingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Congying LiGynecology, Heze Municipal Hospital, China.
Xuewen JiaDepartment of Emergency, Shengli Oilfield Central Hospital, China.
Xueying LiSchool of Nursing, Binzhou Polytechnic, Binzhou, China.
Yan LinClinical Laboratory, The Affiliated Hospital of Qingdao University, Qingdao, China.
Mingzhen GuoMedical Laboratory, Qingdao Women and Children's Hospital of Qingdao University, Qingdao, China.
Sai LiBiology Teaching and Research Department, Fourth Middle School of Qingdao Economic and Technological Development Zone, Qingdao, China.
Chao LiuDepartment of Basic Medicine, College of Pharmacy, Jining Medical University, Rizhao, China.
Yuan LiDepartment of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Shiguo LiuMedical Genetic Department, Prenatal Diagnosis Center, The Affiliated Hospital of Qingdao University, Qingdao, China.ORCID https://orcid.org/0000-0001-6474-4082
Qingdao University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHeze Municipal Hospital · CNJining Medical University · CNShengli Oilfield Central Hospital · CNWeifang University of Science and Technology · CNYangzhou Polytechnic Institute · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unbalanced inflammatory reactions and oxidative stress are inseparably interconnected, and both may play crucial roles in the pathophysiological mechanisms of preeclampsia (PE). In the published previous studies, we have genotyped for SNPs that related to inflammation (rs2227485, rs153109, rs17855750, rs2027432, rs2275913, rs763780, rs4819554, and rs13015714) and oxidative stress (rs1695, rs4680, rs1800566, rs4807542, rs713041, rs7579, rs230813, rs1004467, rs3824755, and rs9932581) to investigate whether these polymorphisms were associated with susceptibility to PE in a Chinese Han population. In this present study, we collected these data of experimental and clinical from above studies for haplotype analysis of inflammation-related SNPs in 631 PE patients and 720 normal pregnancy and oxidative stress-related SNPs in 342 PE patients and 457 normal pregnancies for susceptibility to PE. The data of genotype distribution and allele frequency comparisons after correction for multiple comparisons (P/8 or P/10) showed 2 among the 8 candidate inflammation-related SNPs have significant differences (rs2027432 genotype

Indexed as

GenotypeChinaFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansInflammationNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressPhospholipid Hydroperoxide Glutathione PeroxidasePolymorphism, Single NucleotidePre-EclampsiaPregnancyReceptors, Interleukin-17IL17RA protein, humanNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanPhospholipid Hydroperoxide Glutathione PeroxidaseReceptors, Interleukin-17

Identifiers

PMID32185238
PMCPMC7061132
OpenAlexW3008244873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.