Evidence map›Paper›PMID 32185219›Full record

Observational studyBioMed research international2020

Association of SCN1A, SCN2A, and UGT2B7 Polymorphisms with Responsiveness to Valproic Acid in the Treatment of Epilepsy.

Yuan Lu, Quanping Su, Ming Li, Alimu Dayimu, Xiaoyu Dai, Zhiheng Wang, Fengyuan Che, Fuzhong Xue

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Association BetweenFrontiers in neurology · 2020
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yuan LuDepartment of Biostatistics, School of Public Health, Shandong University, Jinan, 250012 Shandong, China.ORCID https://orcid.org/0000-0002-8046-669X
Quanping SuCentral Laboratory, Linyi People's Hospital, Linyi, 276003 Shandong, China.ORCID https://orcid.org/0000-0003-4922-8375
Ming LiLinyi People's Hospital, Linyi, 276003 Shandong, China.
Alimu DayimuDepartment of Biostatistics, School of Public Health, Shandong University, Jinan, 250012 Shandong, China.
Xiaoyu DaiDepartment of Biostatistics, School of Public Health, Shandong University, Jinan, 250012 Shandong, China.ORCID https://orcid.org/0000-0002-5680-6850
Zhiheng WangDepartment of Biostatistics, School of Public Health, Shandong University, Jinan, 250012 Shandong, China.ORCID https://orcid.org/0000-0001-8490-4522
Fengyuan CheCentral Laboratory, Linyi People's Hospital, Linyi, 276003 Shandong, China.ORCID https://orcid.org/0000-0003-1278-5899
Fuzhong XueDepartment of Biostatistics, School of Public Health, Shandong University, Jinan, 250012 Shandong, China.ORCID https://orcid.org/0000-0003-0378-7956
Shandong University · CNLinyi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe efficacy of valproic acid (VPA) varies widely in clinical treatment of epileptic patients. Our study is aimed at exploring a potential association between polymorphisms of SCN1A, SCN2A, and UGT2B7 genetic factors and VPA responses.

methodsIn this observational study, a total of 114 epileptic patients only treated with VPA for at least 1 year were included to explore the genetic polymorphisms of drug responses (mean follow-up time: 3.68 ± 1.78 years). Thirty-one single-nucleotide polymorphisms (SNPs) in three candidate genes that related with drug-metabolizing enzymes and receptors were genotyped.

resultsOf the 31 SNPs, eight were significantly associated with VPA responses, including rs1381105, rs2162600, rs10197716, rs2119068, rs2119067, rs353116, rs353112 and rs6740895. The interaction between rs10197716 and rs2119068 was the most significantly correlated with VPA responses compared with other combinations (the highest VPA-responsive rate 0.92 versus the lowest VPA-responsive rate 0.33,

conclusionThe study indicated that eight SNPs and SNP-SNP interaction may be associated with VPA responses in Chinese Han epileptic patients. The SNPs were rs1381105 (SCN1A), rs2162600 (SCN1A), rs10197716 (SCN2A), rs2119068 (SCN2A), rs2119067 (SCN2A), rs353116 (SCN2A), rs353112 (SCN2A) and rs6740895 (SCN2A), respectively. The interaction between the three pairs of rs10197716-rs2119068, rs10197716-rs11889342 and rs7598931-rs12233719 was the most significant for VPA. This implied that these SNPs may play an important role in the pharmacogenomics mechanism of valproic acid.

Indexed as

AdultAsian PeopleEpilepsyFemaleGenotypeGlucuronosyltransferaseHumansMaleNAV1.1 Voltage-Gated Sodium ChannelNAV1.2 Voltage-Gated Sodium ChannelPolymorphism, GeneticPolymorphism, Single NucleotideValproic AcidYoung AdultGlucuronosyltransferaseNAV1.1 Voltage-Gated Sodium ChannelNAV1.2 Voltage-Gated Sodium ChannelSCN1A protein, humanSCN2A protein, humanUGT2B7 protein, humanValproic Acid

Identifiers

PMID32185219
PMCPMC7063186
OpenAlexW3007690636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.