Evidence map›Paper›PMID 32185207›Full record

ArticleBioMed research international2020

Green Tea Polyphenols Modulated Cerebral SOD Expression and Endoplasmic Reticulum Stress in Cardiac Arrest/Cardiopulmonary Resuscitation Rats.

Wanxiang Hu, Huihui Wang, Quan Shu, Menghua Chen, Lu Xie

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Wanxiang HuDepartment of Physiology, School of Pre-Clinical Sciences, Guangxi Medical University, Nanning, Guangxi, China.
Huihui WangQilu Medical University, Zibo, Shandong, China.
Quan ShuDepartment of Physiology, School of Pre-Clinical Sciences, Guangxi Medical University, Nanning, Guangxi, China.
Menghua ChenInstitute of Cardiovascular Diseases, The Second Hospital Affiliated to Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0001-6972-9543
Lu XieDepartment of Physiology, School of Pre-Clinical Sciences, Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0003-2645-6439
Guangxi Medical University · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReducing cerebral ischemia-reperfusion injury is crucial for improving survival and neurologic outcomes after cardiac arrest/cardiopulmonary resuscitation (CA/CPR). The purpose of this study is to investigate the neuroprotective effects of green tea polyphenols (GTPs) concern with the modulation of endogenous antioxidation and endoplasmic reticulum stress.

methodsAfter subjecting to CA/CPR, rats were randomized into the saline group (NS,

resultsComparing with that in NS group, GTPs increased the expression of SOD1 and SOD2 at 12 h, 24 h, 48 h, 72 h, and the expression of GRP78 at 24 h and 48 h (

conclusionGTPs exert neuroprotective effects via mechanisms that may be related to the enhancement of endogenous antioxidant capacity and inhibition of endoplasmic reticulum stress in CA/CPR rat models.

Indexed as

AnimalsAntioxidantsApoptosisCardiopulmonary ResuscitationCaspase 12Caspase 3Cerebral CortexDisease Models, AnimalEndoplasmic Reticulum StressHeart ArrestHeat-Shock ProteinsMaleNeuronsNeuroprotective AgentsPolyphenolsRatsAntioxidantsCaspase 12Caspase 3Ddit3 protein, ratHeat-Shock ProteinsNeuroprotective AgentsPolyphenolsSod1 protein, ratSuperoxide DismutaseSuperoxide Dismutase-1Superoxide Dismutase 2TeaTranscription Factor CHOP

Identifiers

PMID32185207
PMCPMC7060848
OpenAlexW3007210999

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.