Evidence map›Paper›PMID 32185173›Full record

ReviewFrontiers in cell and developmental biology2020

Lipid Mediated Regulation of Adult Stem Cell Behavior.

Marie Clémot, Rafael Sênos Demarco, D Leanne Jones

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Metabolic regulation in the senescence process of stem cells.Stem cells translational medicine · 2025
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Editorial: Metabolic regulation of stem cell fate.Frontiers in cell and developmental biology · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marie ClémotDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
Rafael Sênos DemarcoDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
D Leanne JonesDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · US

Funding

Characterization of Age-Related Changes in Stem Cell BehaviorR01AG028092 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE · 2007 to 2016
$3.6M
Lipid mediated regulation of stem cell behavior and tissue homeostasisR01GM135767 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JONES, DANA LEANNE · 2020 to 2023
$1.8M
Regulation of intestinal stem cell behavior by occluding junctionsR01DK105442 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE · 2017 to 2020
$1.7M
NIA NIH HHS R01 AG028092NIDDK NIH HHS R01 DK105442NIGMS NIH HHS R01 GM135767
6 · The paper itself

Abstract

Adult stem cells constitute an important reservoir of self-renewing progenitor cells and are crucial for maintaining tissue and organ homeostasis. The capacity of stem cells to self-renew or differentiate can be attributed to distinct metabolic states, and it is now becoming apparent that metabolism plays instructive roles in stem cell fate decisions. Lipids are an extremely vast class of biomolecules, with essential roles in energy homeostasis, membrane structure and signaling. Imbalances in lipid homeostasis can result in lipotoxicity, cell death and diseases, such as cardiovascular disease, insulin resistance and diabetes, autoimmune disorders and cancer. Therefore, understanding how lipid metabolism affects stem cell behavior offers promising perspectives for the development of novel approaches to control stem cell behavior either

Indexed as

fatty acidslipidmetabolismnichestem cells

Identifiers

PMID32185173
PMCPMC7058546
OpenAlexW3008488814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.