Evidence map›Paper›PMID 32184959›Full record

ArticleACS medicinal chemistry letters2020

Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury.

Jonathan E Palmer, Breanna M Brietske, Tyler C Bate, Erik A Blackwood, Manasa Garg, Christopher C Glembotski, Christina B Cooley

Open access · greenAbstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. HJournal of medicinal chemistry · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jonathan E PalmerDepartment of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas 78212, United States.
Breanna M BrietskeDepartment of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas 78212, United States.
Tyler C BateDepartment of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas 78212, United States.
Erik A BlackwoodSan Diego State University Heart Institute and Department of Biology, San Diego State University, San Diego, California 92182, United States.
Manasa GargDepartment of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas 78212, United States.
Christopher C GlembotskiSan Diego State University Heart Institute and Department of Biology, San Diego State University, San Diego, California 92182, United States.
Christina B CooleyDepartment of Chemistry, Trinity University, One Trinity Place, San Antonio, Texas 78212, United States.
Trinity University · USSan Diego State University · US

Funding

The ER Stress-Induced Selenoprotein, SelenoS, Regulates Proteostasis and Cardiac HypertrophyR01HL149931 · NHLBI · UNIVERSITY OF ARIZONA · PI GLEMBOTSKI, CHRIS · 2020 to 2023
$1.7M
Harnessing the Adaptive ER Stress Response in Myocardial IschemiaR01HL135893 · NHLBI · UNIVERSITY OF ARIZONA · PI GLEMBOTSKI, CHRIS · 2017 to 2020
$1.5M
ATF6 is Required for ANP Secretion from the HeartR01HL141463 · NHLBI · UNIVERSITY OF ARIZONA · PI GLEMBOTSKI, CHRIS · 2019 to 2022
$1.5M
NHLBI NIH HHS R01 HL135893NHLBI NIH HHS R01 HL141463NHLBI NIH HHS R01 HL149931
6 · The paper itself

Abstract

We describe here the design, synthesis, and biological evaluation of a reactive oxygen species (ROS)-activatable prodrug for the selective delivery of

Identifiers

PMID32184959
PMCPMC7073885
OpenAlexW2986904428

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.