ArticleACS medicinal chemistry letters2020
Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
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Article in ACS medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- 5‑Nitrofuran-Semicarbazone Hybrids as Antitrypanosomal Agents: Structure-Activity Relationship and Nitroreductase Activation.ACS medicinal chemistry letters · 2026Article
- Optimization of Physicochemical Properties and ADME for 2,4-Substituted 1Journal of medicinal chemistry · 2025Article
- Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents.ACS infectious diseases · 2025Article
- Pharmacophore Identification and Structure-Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors ofJournal of medicinal chemistry · 2024Article
- Computer-aided pattern scoring - A multitarget dataset-driven workflow to predict ligands of orphan targets.Scientific data · 2024Article
- Medicinal Polypharmacology in the Clinic - Translating the Polypharmacolome into Therapeutic Benefit.Pharmaceutical research · 2024Article
- Evolution of the Quinoline Scaffold for the Treatment of Leishmaniasis: A Structural Perspective.Pharmaceuticals (Basel, Switzerland) · 2024Review
- 4-Aminoquinoline as a privileged scaffold for the design of leishmanicidal agents: structure-property relationships and key biological targets.Frontiers in chemistry · 2024Review
- Medicinal polypharmacology-a scientific glossary of terminology and concepts.Frontiers in pharmacology · 2024Review
- Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy.Journal of medicinal chemistry · 2023Article
- A Novel Protocol for the Synthesis of 1,2,4-Oxadiazoles Active against Trypanosomatids and Drug-Resistant Leukemia Cell Lines.Tropical medicine and infectious disease · 2022Article
- Identification of Leucinostatins fromACS omega · 2022Article
- Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.Journal of medicinal chemistry · 2021Article
- Collaborative virtual screening to elaborate an imidazo[1,2-RSC medicinal chemistry · 2021Article
- Dual-Stage Picolinic Acid-Derived Inhibitors ofACS medicinal chemistry letters · 2020Article
- Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead forJournal of medicinal chemistry · 2020Article
- Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity.RSC medicinal chemistry · 2020Article
- Structure-Bioactivity Relationships of Lapatinib Derived Analogs againstACS medicinal chemistry letters · 2020Article
Corrections and comments
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Authors and funding
24 authors at 4 institutions in 1 country.
Baljinder SinghDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Jean A BernatchezSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Laura-Isobel McCallSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Claudia M CalvetSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Jasmin AckermannSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Julia M SouzaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Diane ThomasSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Everton M SilvaSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Kelly A BachovchinDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Dana M KlugDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Hitesh B JalaniDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Seema BagDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Melissa J BuskesDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Susan E LeedExperimental Therapeutics, Walter Reed Army Institute of Research, 2460 Linden Lane, Silver Spring, Maryland 20910, United States.
Norma E RoncalExperimental Therapeutics, Walter Reed Army Institute of Research, 2460 Linden Lane, Silver Spring, Maryland 20910, United States.
Erica C PennExperimental Therapeutics, Walter Reed Army Institute of Research, 2460 Linden Lane, Silver Spring, Maryland 20910, United States.
Jessey ErathDepartment of Microbiology, New York University School of Medicine, 430 East 29th Street, New York, New York 10010, United States.
Ana RodriguezDepartment of Microbiology, New York University School of Medicine, 430 East 29th Street, New York, New York 10010, United States.
Richard J SciottiExperimental Therapeutics, Walter Reed Army Institute of Research, 2460 Linden Lane, Silver Spring, Maryland 20910, United States.
Robert F CampbellExperimental Therapeutics, Walter Reed Army Institute of Research, 2460 Linden Lane, Silver Spring, Maryland 20910, United States.
James McKerrowSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Jair L Siqueira-NetoSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States.
Lori FerrinsDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
Michael P PollastriDepartment of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.
University of California San Diego · USNortheastern University · USWalter Reed Army Institute of Research · USNew York University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.