Solid Sirolimus Self-microemulsifying Drug Delivery System: Development and Evaluation of Tablets with Sustained Release Property.

Chun Tao, Xu Wen, Qian Zhang, Hongtao Song

Abstract read

In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Effect of Surface Property on the Release and Oral Absorption of Solid Sirolimus-Containing Self-microemulsifying Drug Delivery System.AAPS PharmSciTech · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chun TaoDepartment of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University (Fuzhou General Hospital), Fuzhou 350025, PR China.

Xu WenDepartment of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University (Fuzhou General Hospital), Fuzhou 350025, PR China.

Qian ZhangDepartment of Inorganic Chemistry, College of Pharmacy, Fujian Medical University, Fuzhou 350108, PR China.

Hongtao SongDepartment of Pharmacy, Fuzong Clinical Medical College of Fujian Medical University (Fuzhou General Hospital), Fuzhou 350025, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physically adsorbed by microcrystalline cellulose (MCC). The sustained release of SRL was achieved by addition of hydroxypropyl methylcellulose (HPMC) to prepare tablets. The formulation of the tablets was optimized by single factor test and orthogonal design. The optimal formulation was composed of 10% of HPMC 100lv and 5% of HPMC K4M. The

Indexed as

Bio-equivalentSelf-microemulsifying drug delivery systemSirolimusSustained releaseTablet

Identifiers

PMID32184836

DOI10.22037/ijpr.2019.1100847

PMCPMC7059041

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.