Evidence map›Paper›PMID 32184780›Full record

ArticleFrontiers in immunology2020

Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy.

Katerina Zachova, Petr Kosztyu, Josef Zadrazil, Karel Matousovic, Karel Vondrak, Petr Hubacek, Bruce A Julian, Zina Moldoveanu, Zdenek Novak, Klara Kostovcikova and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  12. The Role of NLRP3 Inflammasome in IgA Nephropathy.Medicina (Kaunas, Lithuania) · 2022
    Review
  13. Article
  14. Article
  15. The mucosal immune system and IgA nephropathy.Seminars in immunopathology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Katerina ZachovaDepartment of Immunology, Faculty of Medicine and Dentistry, University Hospital Olomouc, Palacky University Olomouc, Olomouc, Czechia.
Petr KosztyuDepartment of Immunology, Faculty of Medicine and Dentistry, University Hospital Olomouc, Palacky University Olomouc, Olomouc, Czechia.
Josef ZadrazilDepartment of Internal Medicine III Nephrology, Rheumatology and Endocrinology, University Hospital Olomouc, Palacky University Olomouc, Olomouc, Czechia.
Karel MatousovicDepartment of Medicine, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czechia.
Karel VondrakDepartment of Pediatrics, Second Faculty of Medicine, Charles University, Prague, Czechia.
Petr HubacekDepartment of Medical Microbiology, Second Faculty of Medicine, University Hospital Motol, Charles University, Prague, Czechia.
Bruce A JulianDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
Zina MoldoveanuDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL, United States.
Zdenek NovakDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL, United States.
Klara KostovcikovaLaboratory of Cellular and Molecular Immunology, Institute of Microbiology, Czech Academy of Sciences, Prague, Czechia.
Milan RaskaDepartment of Immunology, Faculty of Medicine and Dentistry, University Hospital Olomouc, Palacky University Olomouc, Olomouc, Czechia.
Jiri MesteckyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USCharles University · CZPalacký University Olomouc · CZUniversity Hospital Olomouc · CZCzech Academy of Sciences, Institute of Microbiology · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African Americans. Polymeric IgA1 with galactose-deficient hinge-region glycans is recognized as auto-antigen by glycan-specific antibodies, leading to formation of circulating immune complexes with nephritogenic consequences. Because human B cells infected

Indexed as

Racial GroupsB-LymphocytesCzech RepublicEpstein-Barr Virus InfectionsGalactoseGlomerulonephritis, IGAHerpesvirus 4, HumanHumansImmunoglobulin AInfantPrevalenceGalactoseImmunoglobulin AEBV-Epstein-Barr virusIgAIgA nephropathymucosal immunologyracial distribution

Identifiers

PMID32184780
PMCPMC7058636
OpenAlexW3007763950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.