Evidence map›Paper›PMID 32184720›Full record

ArticleFrontiers in pharmacology2020

Maternal 25-Hydroxyvitamin D Deficiency Promoted Metabolic Syndrome and Downregulated Nrf2/CBR1 Pathway in Offspring.

Jianqiong Zheng, Xiaohui Liu, Bingbing Zheng, Zhenzhen Zheng, Hongping Zhang, Jiayong Zheng, Congcong Sun, Haiying Chen, Jie Yang, Zuo Wang and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Jianqiong ZhengDepartment of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Xiaohui LiuDepartment of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Bingbing ZhengDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Zhenzhen ZhengDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Hongping ZhangDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Jiayong ZhengDepartment of Wenzhou Key Laboratory of Gynecology and Obstetrics, Wenzhou People's Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Congcong SunDepartment of Wenzhou Key Laboratory of Gynecology and Obstetrics, Wenzhou People's Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Haiying ChenDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Jie YangDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Zuo WangDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Meimei LinDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Jingjing ChenDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Qingdiao ZhouDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Zhi ZhengDepartment of Obstetrics and Gynecology, Wenzhou People's Hospital, the Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Xiaoming XuDepartment of Wenzhou Key Laboratory of Gynecology and Obstetrics, Wenzhou People's Hospital, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Hao YingDepartment of Obstetrics, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.
Wenzhou Medical University · CNShanghai First Maternity and Infant Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D deficiency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlying mechanism of induced metabolic syndrome (MetS) in the offspring in vitamin D deficient pregnant mothers remains unclear. We identified that maternal 25-hydroxyvitamin D deficiency enhances oxidative stress, which leads to the development of MetS in the mother and her offspring. Further, immunohistochemical, Western blotting, and qRT-PCR analyses revealed that maternal 25-hydroxyvitamin D deficiency inhibited the activation of the Nrf2/carbonyl reductase 1 (CBR1) pathway in maternal placenta, liver, and pancreas, as well as the offspring's liver and pancreas. Further analyses uncovered that application of 25-hydroxyvitamin D activated the Nrf2/CBR1 pathway, relieving the oxidative stress in BRL cells, suggesting that 25-hydroxyvitamin D regulates oxidative stress in offspring and induces the activation of the Nrf2/CBR1 pathway. Taken together, our study finds that maternal 25-hydroxyvitamin D deficiency is likely to result in offspring's MetS probably

Indexed as

25-hydroxyvitamin D deficiencymaternalmetabolic syndromeNrf2/CBR1 pathwayoffspring

Identifiers

PMID32184720
PMCPMC7058637
OpenAlexW3008975075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.