ArticleFrontiers in neuroscience2020
Restoring Somatosensation: Advantages and Current Limitations of Targeting the Brainstem Dorsal Column Nuclei Complex.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Direct Prosthesis Force Control with Tactile Feedback May Connect with the Internal Model.medRxiv : the preprint server for health sciences · 2024Article
- Implications for brainstem recovery from studies in primates after sensory loss from arm.Neural regeneration research · 2024Article
- Utilization of peripheral nerve feedback at a preconscious level.Frontiers in neuroscience · 2024Article
- Regressive changes in sizes of somatosensory cuneate nucleus after sensory loss in primates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The science and engineering behind sensitized brain-controlled bionic hands.Physiological reviews · 2022Review
- Encoding of limb state by single neurons in the cuneate nucleus of awake monkeys.Journal of neurophysiology · 2021Article
- Human Somatosensory Processing and Artificial Somatosensation.Cyborg and bionic systems (Washington, D.C.) · 2021Review
- Tapping Into the Language of Touch: Using Non-invasive Stimulation to Specify Tactile Afferent Firing Patterns.Frontiers in neuroscience · 2020Review
- Dorsal Column Nuclei Neural Signal Features Permit Robust Machine-Learning of Natural Tactile- and Proprioception-Dominated Stimuli.Frontiers in systems neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current neural prostheses can restore limb movement to tetraplegic patients by translating brain signals coding movements to control a variety of actuators. Fast and accurate somatosensory feedback is essential for normal movement, particularly dexterous tasks, but is currently lacking in motor neural prostheses. Attempts to restore somatosensory feedback have largely focused on cortical stimulation which, thus far, have succeeded in eliciting minimal naturalistic sensations. Yet, a question that deserves more attention is whether the cortex is the best place to activate the central nervous system to restore somatosensation. Here, we propose that the brainstem dorsal column nuclei are an ideal alternative target to restore somatosensation. We review some of the recent literature investigating the dorsal column nuclei functional organization and neurophysiology and highlight some of the advantages and limitations of the dorsal column nuclei as a future neural prosthetic target. Recent evidence supports the dorsal column nuclei as a potential neural prosthetic target, but also identifies several gaps in our knowledge as well as potential limitations which need to be addressed before such a goal can become reality.
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Registered trials
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