Evidence map›Paper›PMID 32184654›Full record

ArticleBreast cancer (Dove Medical Press)2020

Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients.

Shelly Wen, Lucy Manuel, Moira Doolan, Justin Westhuyzen, Thomas P Shakespeare, Noel J Aherne

Abstract read
In one paragraph

Article in Breast cancer (Dove Medical Press), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shelly WenDepartment of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia.
Lucy ManuelDepartment of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia.
Moira DoolanDepartment of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia.
Justin WesthuyzenDepartment of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia.ORCID 0000-0002-4812-8973
Thomas P ShakespeareDepartment of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia.
Noel J AherneDepartment of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTriple negative breast cancer (TNBC) accounts for approximately 15% of breast cancer cases and is associated with a poor prognosis. In this retrospective study of patients undergoing radiation therapy as part of their treatment, disease-free survival (DFS) and overall survival (OS) of TNBC patients were examined in relation to clinical and treatment-related factors. PATIENTS AND

methodsThe electronic records of 214 consecutive TNBC patients treated with surgery followed by radiotherapy at the Mid North Coast Cancer Institute between 2006 and 2016 were reviewed. Overall survival and DFS times were analyzed using the Kaplan-Meier method; multivariate Cox proportional hazard regression modelling was used to assess the significance of prognostic factors.

resultsThe majority of tumors were T1 (51.9%), followed by T2 (39.2%) and T3 (6.1%). For the whole group, mean DFS was 106.4 (SD 48.7) months; OS 109.4 (SD 52.1) months. Radiotherapy technique, fractionation protocol and laterality were not significant factors for DFS or OS (

conclusionAdvanced disease exhibited by tumor size > 5cm and positive nodal status is associated with poorer DFS in TNBC patients. Radiotherapy technique or fractionation protocol were not associated with differences in DFS or OS in our patient cohort.

Indexed as

dose fractionationmastectomyradiotherapysurvival analysistriple negative breast neoplasms

Identifiers

PMID32184654
PMCPMC7064282

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.