ArticleInternational journal of nanomedicine2020
Multi-Layered Polyamide/Collagen Scaffolds with Topical Sustained Release of N-Acetylcysteine for Promoting Wound Healing.
Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- N-Acetylcysteine Applied to Hydrogels: A Comprehensive Systematic Review.Gels (Basel, Switzerland) · 2026Review
- Recent Advances in Smart Wound Healing Patches: From Passive Dressings to Intelligent Theranostic Systems.Cureus · 2026Review
- An Anti-Inflammatory and Pro-Angiogenic Porous Aloe Polysaccharide-Collagen Dressing Accelerates Wound Healing.ACS applied bio materials · 2025Article
- Mechanistic study of the stabilization of dentin-bonded restorative interfaces via collagen reinforcement by multi-acrylamides.Dental materials : official publication of the Academy of Dental Materials · 2024Article
- A core-shell-type nanosystem promotes diabetic wound healing through Photothermal-responsive release of transforming growth factor β.Journal of nanobiotechnology · 2024Article
- Enhancing pressure ulcer healing and tissue regeneration by using N-acetyl-cysteine loaded carboxymethyl cellulose/gelatin/sodium alginate hydrogel.Biomedical engineering letters · 2024Article
- Pre-Incisional and Multiple Intradermal Injection of N-Acetylcysteine Slightly Improves Incisional Wound Healing in an Animal Model.International journal of molecular sciences · 2024Article
- Collagen-Based Scaffolds for Chronic Skin Wound Treatment.Gels (Basel, Switzerland) · 2024Review
- Engineered nanovesicles from stromal vascular fraction promote angiogenesis and adipogenesis inside decellularized adipose tissue through encapsulating growth factors.Scientific reports · 2023Article
- Amphiphilic and fatigue-resistant organohydrogels for small-diameter vascular grafts.Science advances · 2022Article
- Recent Progress and Potential Biomedical Applications of Electrospun Nanofibers in Regeneration of Tissues and Organs.Polymers · 2022Review
- [Research advances on the biomechanical micro- environment facilitated wound repair through the regulation of cell migration].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2022Review
- Nanobiotechnology: Applications in Chronic Wound Healing.International journal of nanomedicine · 2022Review
- Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds.BioMed research international · 2022Review
- Review
- Polyamide/Poly(Amino Acid) Polymers for Drug Delivery.Journal of functional biomaterials · 2021Review
- Glibenclamide Nanocrystal-Loaded Bioactive Polymeric Scaffolds for Skin Regeneration: In Vitro Characterization and Preclinical Evaluation.Pharmaceutics · 2021Article
- The Role of Antioxidants on Wound Healing: A Review of the Current Evidence.Journal of clinical medicine · 2021Review
- Improvement of ECM-based bioroot regeneration via N-acetylcysteine-induced antioxidative effects.Stem cell research & therapy · 2021Article
- Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model.Regenerative biomaterials · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired wound healing might be associated with many issues, especially overactive of reactive oxygen species (ROS), deficiency of blood vessels and immature of epidermis. N-acetylcysteine (NAC), as an antioxidant, could solve these problems by inhibiting overreactive of ROS, promoting revascularization and accelerating re-epithelialization. How to deliver NAC in situ with a controllable releasing speed still remain a challenge. MATERIALS AND
methodsIn this study, we combined collagen (Col) with N-acetylcysteine to perform the characteristics of sustained release and chemically crosslinked Col/NAC composite with polyamide (PA) nanofibers to enhance the mechanical property of collagen and fabricated this multi-layered scaffold (PA-Col/NAC scaffold). The physical properties of the scaffolds such as surface characteristics, water absorption and tensile modulus were tested. Meanwhile, the ability to promote wound healing in vitro and in vivo were investigated.
resultsThese scaffolds were porous and performed great water absorption. The PA-Col/NAC scaffold could sustainably release NAC for at least 14 days. After cell implantation, PA-Col/NAC scaffold showed better cell proliferation and cell migration than the other groups. In vivo, PA-Col/NAC scaffolds could promote wound healing best among all the groups.
conclusionThe multi-layered scaffolds could obviously accelerate the process of wound healing and exert better and prolonged effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.