Evidence map›Paper›PMID 32184252›Full record

Trial reportmBio2020

Linking Human Milk Oligosaccharides, Infant Fecal Community Types, and Later Risk To Require Antibiotics.

Bernard Berger, Nadine Porta, Francis Foata, Dominik Grathwohl, Michèle Delley, Deborah Moine, Aline Charpagne, Léa Siegwald, Patrick Descombes, Philippe Alliet and 4 more

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
11.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 171 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Bernard BergerDepartment of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland bernard.berger@rdls.nestle.com.ORCID 0000-0002-4468-7700
Nadine PortaDepartment of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Francis FoataDepartment of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Dominik GrathwohlClinical Development Research Unit, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Michèle DelleyDepartment of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Deborah MoineDepartment of Analytical Sciences, Institute of Food Safety & Analytical Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Aline CharpagneDepartment of Analytical Sciences, Institute of Food Safety & Analytical Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Léa SiegwaldDepartment of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Patrick DescombesDepartment of Analytical Sciences, Institute of Food Safety & Analytical Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Philippe AllietJessa Hospital, Department of Paediatrics, Hasselt, Belgium.
Giuseppe PuccioDipartimento Materno Infantile AOUP Paolo Giaccone, Università di Palermo, Palermo, Italy.
Philippe SteenhoutNestlé Nutrition R&D, Vevey, Switzerland.
Annick MercenierDepartment of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Norbert SprengerDepartment of Gastro-Intestinal Health, Nestlé Institute of Health Sciences, Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland.
Nestlé (Switzerland) · CHJessa Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human milk oligosaccharides (HMOs) may provide health benefits to infants partly by shaping the development of the early-life intestinal microbiota. In a randomized double-blinded controlled multicentric clinical trial, healthy term infants received either infant formula (control) or the same formula with two HMOs (2'-fucosyllactose and lacto-N-

Indexed as

Gastrointestinal MicrobiomeAnti-Bacterial AgentsBacteriaBreast FeedingDouble-Blind MethodFecesFemaleHumansInfantInfant FormulaInfant, NewbornMaleMilk, HumanOligosaccharidesRNA, Ribosomal, 16SAnti-Bacterial AgentsOligosaccharidesRNA, Ribosomal, 16S2′FLantibioticsBifidobacteriumfecal community typesformulahuman milk oligosaccharidesinfantLNnTmicrobiota

Identifiers

PMID32184252
PMCPMC7078481
OpenAlexW3011857190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.