Evidence map›Paper›PMID 32184236›Full record

ArticlemBio2020

A Solution to Antifolate Resistance in Group B

Schuyler A Chambers, Rebecca E Moore, Kelly M Craft, Harrison C Thomas, Rishub Das, Shannon D Manning, Simona G Codreanu, Stacy D Sherrod, David M Aronoff, John A McLean and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. The gut as a central hub for multi-organ crosstalk in aging.Cellular and molecular life sciences : CMLS · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Antibiotic perturbations to the gut microbiome.Nature reviews. Microbiology · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Biology of human milk oligosaccharides: From basic science to clinical evidence.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Schuyler A Chambers *Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-3557-830X
Rebecca E Moore *Department of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Kelly M CraftDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0001-9753-2801
Harrison C ThomasDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Rishub DasDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Shannon D ManningDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, Michigan, USA.
Simona G CodreanuDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Stacy D SherrodDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
David M AronoffDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John A McLeanDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA.
Jennifer A GaddyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA jennifer.a.gaddy@vanderbilt.edu steven.d.townsend@vanderbilt.edu.ORCID 0000-0002-2192-4224
Steven D TownsendDepartment of Chemistry, Vanderbilt University, Nashville, Tennessee, USA jennifer.a.gaddy@vanderbilt.edu steven.d.townsend@vanderbilt.edu.ORCID 0000-0001-5362-7235
Vanderbilt University · USMichigan State University · USVanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · US

Funding

Repurposing misoprostol to prevent recurrence of Clostridium difficile infectionU01TR002398 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DOSTER, RYAN S, DUBBERKE, ERIK R · 2018 to 2019
$3.1M
Determining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5M
The Role of macrophages in chorioamnionitis and group B streptococcal infectionsR01AI134036 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M · 2017 to 2021
$2.4M
NCATS NIH HHS U01 TR002398NIAID NIH HHS R01 AI134036NICHD NIH HHS R01 HD090061
6 · The paper itself

Abstract

Adjuvants can be used to potentiate the function of antibiotics whose efficacy has been reduced by acquired or intrinsic resistance. In the present study, we discovered that human milk oligosaccharides (HMOs) sensitize strains of group B

Indexed as

Drug Resistance, BacterialAnti-Bacterial AgentsHumansMetabolic Networks and PathwaysMetabolomicsMilk, HumanOligosaccharidesStreptococcus agalactiaeTandem Mass SpectrometryTrimethoprimAnti-Bacterial AgentsOligosaccharidesTrimethoprimadjuvantsantifolate drugsgroup B Streptococcushuman milk oligosaccharidesresistance

Identifiers

PMID32184236
PMCPMC7078465
OpenAlexW3011580388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.