Evidence map›Paper›PMID 32184195›Full record

ArticleBone2020

Hip load capacity and yield load in men and women of all ages.

J H Keyak, T S Kaneko, S Khosla, S Amin, E J Atkinson, T F Lang, J D Sibonga

Open access · greenAbstract read
In one paragraph

Article in Bone, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. A new hip fracture risk index derived from FEA-computed proximal femur fracture loads and energies-to-failure.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

J H KeyakDepartment of Radiological Sciences, University of California, Irvine, CA, USA; Department of Biomedical Engineering, University of California, Irvine, CA, USA; Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA, USA. Electronic address: jhkeyak@uci.edu.
T S KanekoDepartment of Radiological Sciences, University of California, Irvine, CA, USA.
S KhoslaDivision of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
S AminDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
E J AtkinsonDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
T F LangDepartment of Radiology and Biomedical Imaging and School of Dentistry, University of California, San Francisco, CA, USA.
J D SibongaDivision of Biomedical Research and Environmental Sciences, NASA Lyndon B. Johnson Space Center, Houston, TX, USA.
Mayo Clinic in Arizona · USUniversity of California, Irvine · USJohnson Space Center · USMayo Clinic in Florida · USUniversity of California, San Francisco · US

Funding

ZOVIRAX CREAM TO TREAT HERPES LABIALIS IN ADOLESCENTSM01RR000827 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAAS, RICHARD H · 1985 to 2010
$74.3M
ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
EPIDEMIOLOGY OF AGE-RELATED BONE LOSS, &FRACTURESR01AR027065 · NIAMS · MAYO CLINIC ROCHESTER · PI AMIN, SHREYASEE, KHOSLA, SUNDEEP · 1986 to 2020
$14.9M
Bone quality by vQCT and HR-pQCT: translation to multi-center clinical researchR01AR060700 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BURGHARDT, ANDREW JOHN, LANG, THOMAS F · 2011 to 2014
$2.0M
Age-related changes in proximal femoral strength in men and womenR01AG028832 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANG, THOMAS F · 2007 to 2011
$1.9M
CT-based modeling to analyze variation in skeletal response to osteoporosis drugsR01AR064140 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KEYAK, JOYCE H., LANG, THOMAS F · 2013 to 2016
$1.2M
Race differences in hip strength, density and geometryR01AR046197 · NIAMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI LANG, THOMAS F · 2001 to 2004
$1.0M
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–
NCRR NIH HHS M01 RR000585NCRR NIH HHS M01 RR000827NIAMS NIH HHS R01 AR027065NIAMS NIH HHS R01 AR046197NIAMS NIH HHS R01 AR060700NIAMS NIH HHS R01 AR064140NIA NIH HHS N01 AG012100NIA NIH HHS R01 AG028832
6 · The paper itself

Abstract

Quantitative computed tomography (QCT) based finite element (FE) models can compute subject-specific proximal femoral strengths, or fracture loads, that are associated with hip fracture risk. These fracture loads are more strongly associated with measured fracture loads than are DXA and QCT measures and are predictive of hip fracture independently of DXA bone mineral density (BMD). However, interpreting FE-computed fracture loads of younger subjects for the purpose of evaluating hip fracture risk in old age is challenging due to limited reference data. The goal of this study was to address this issue by providing reference data for male and female adult subjects of all ages. QCT-based FE models of the left proximal femur of 216 women and 181 men, age 27 to 90 years, from a cohort of Rochester, MN residents were used to compute proximal femoral load capacities, i.e. the maximum loads that can be supported, in single-limb stance and posterolateral fall loading (Stance_LC and Fall_LC, respectively) [US Patent No. 9,245,069] and yield load under fall loading (Fall_yield). To relate these measures to information about hip fracture, the CT scanner and calibration phantom were cross-calibrated with those from our previous prospective study of hip fracture in older fracture and control subjects, the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort. We then plotted Stance_LC

Indexed as

Hip FracturesAdultAgedAged, 80 and overBone DensityCross-Sectional StudiesFemaleFemurFinite Element AnalysisHumansMaleMiddle AgedProspective StudiesBone strengthFemurFinite element analysisHip fractureOsteoporosisQuantitative computed tomography

Identifiers

PMID32184195
PMCPMC7354222
OpenAlexW3011085554

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.