ArticleNeurobiology of aging2020
Age-related reduction in motor adaptation: brain structural correlates and the role of explicit memory.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic investigation reveals dissociable effects of ageing on implicit and explicit components of sensorimotor learning.Nature human behaviour · 2026Pooled it
- Acute pain impairs locomotor learning and retention in older adults.The journal of pain · 2026Trial
- Effects of transcranial electrical stimulation of the cerebellum, parietal cortex, anterior cingulate, and motor cortex on postural adaptation.Scientific reports · 2025Trial
- The dynamic bodily self across lifespan: Agency, ownership, and the plasticity of internal body models.Psychonomic bulletin & review · 2026Review
- Better immediate declarative memory is associated with forgetting during locomotor adaptation in chronic stroke and in older adults.medRxiv : the preprint server for health sciences · 2026Article
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- Large reaching datasets quantify the impact of age, sex/gender, and experience on motor control.Communications psychology · 2026Article
- Visuomotor adaptation and savings are preserved in individuals with depression.Journal of motor learning and development · 2025Article
- Effect of simple motor exercise on motor adaptation in complex dynamic tasks: exploring age-related variations.Journal of neurophysiology · 2025Article
- Age-Related Positivity Bias in Emotion Recognition Is Linked to Lower Cognitive Performance and Altered Amygdala-Orbitofrontal Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Repetition Hampers Flexible Object Manipulation Under Visual Uncertainty.The European journal of neuroscience · 2025Article
- Dynamic alterations in cortical activation during motor adaptation in table tennis using whole‑brain fNIRS.Scientific reports · 2025Article
- Unlocking motor reserve: behavioral and neuroimaging correlates of locomotor adaptability from youth to old age.Frontiers in systems neuroscience · 2025Article
- Review
- Differential Aging Effects on Implicit and Explicit Sensorimotor Learning.bioRxiv : the preprint server for biology · 2024Article
- Article
- Early-Stage Alzheimer's Disease Affects Fast But Not Slow Adaptive Processes in Motor Learning.eNeuro · 2024Article
- Quantifying motor adaptation in a sport-specific table tennis setting.Scientific reports · 2024Article
- Effects of online and offline trigeminal nerve stimulation on visuomotor learning.Frontiers in human neuroscience · 2024Article
- Structural brain changes in emotion recognition across the adult lifespan.Social cognitive and affective neuroscience · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The adaption of movement to changes in the environment varies across life span. Recent evidence has linked motor adaptation and its reduction with age to differences in "explicit" learning processes. We examine differences in brain structure and cognition underlying motor adaptation in a population-based cohort (n = 322, aged 18-89 years) using a visuomotor learning task and structural magnetic resonance imaging. Reduced motor adaptation with age was associated with reduced volume in striatum, prefrontal, and sensorimotor cortical regions, but not cerebellum. Medial temporal lobe volume, including the hippocampus, became a stronger determinant of motor adaptation with age. Consistent with the role of the medial temporal lobes, declarative long-term memory showed a similar interaction, whereby memory was more positively correlated with motor adaptation with increasing age. By contrast, visual short-term memory was related to motor adaptation, independently of age. These results support the hypothesis that cerebellar learning is largely unaffected in old age, and the reduction in motor adaptation with age is driven by a decline in explicit memory systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.