Evidence map›Paper›PMID 32184026›Full record

Trial reportClinical nutrition (Edinburgh, Scotland)2020

Body composition during outpatient treatment of severe acute malnutrition: Results from a randomised trial testing different doses of ready-to-use therapeutic foods.

Suvi T Kangas, Pernille Kaestel, Cécile Salpéteur, Victor Nikièma, Leisel Talley, André Briend, Christian Ritz, Henrik Friis, Jonathan C Wells

Abstract readEquivalence TrialRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical nutrition (Edinburgh, Scotland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Suvi T KangasDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Expertise and Advocacy Department, Action Against Hunger (ACF), Paris, France. Electronic address: suvi_kangas@hotmail.com.
Pernille KaestelDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Cécile SalpéteurExpertise and Advocacy Department, Action Against Hunger (ACF), Paris, France.
Victor NikièmaNutrition and Health Department, Action Against Hunger (ACF) Mission in Burkina Faso, Burkina Faso.
Leisel TalleyCenters for Disease Control and Prevention, Atlanta, USA.
André BriendDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark; Center for Child Health Research, University of Tampere School of Medicine, FIN-33014 Tampere University, Tampere, Finland.
Christian RitzDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Henrik FriisDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Jonathan C WellsChildhood Nutrition Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK; Population, Policy, and Practice Programme, UCL Great Ormond Street Institute of Child Health, London, UK.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

BACKGROUND &

aimsTreatment of children with uncomplicated severe acute malnutrition (SAM) is based on ready-to-use therapeutic foods (RUTF) prescribed based on body weight and administered at home. Treatment performance is typically monitored through weight gain. We previously reported that a reduced dose of RUTF resulted in weight gain velocity similar to standard dose. Here we investigate the change in body composition of children treated for SAM and compare it to community controls, and describe the effect of a reduced RUTF dose on body composition at recovery.

methodsBody composition was measured via bio-electrical impedance analysis at admission and recovery among a sub-group of children with SAM participating in a clinical trial and receiving a reduced or a standard dose of RUTF. Non-malnourished children were measured to represent community controls. Linear mixed regression models were fitted.

resultsWe obtained body composition data from 452 children at admission, 259 at recovery and 97 community controls. During SAM treatment the average weight increased by 1.20 kg of which 0.55 kg (45%) was fat-free mass (FFM) and 0.67 kg (55%) was fat mass (FM). At recovery, children treated for SAM had 1.27 kg lower weight, 0.38 kg lower FFM, and 0.90 kg lower FM compared to community controls. However, their fat-free mass index (FFMI) was not different from community controls (Δ0.2 kg/m

conclusionsAlmost half of the weight gain during SAM treatment was FFM. Compared to community controls, children recovered from SAM had a lower FM while their height-adjusted FFM was similar. There was no evidence of a differential effect of a reduced RUTF dose on the tissue accretion of treated children when compared to standard treatment.

Indexed as

Fast FoodsAdipose TissueAmbulatory CareAnthropometryBody CompositionBody WeightBurkina FasoCase-Control StudiesFemaleHumansInfantLinear ModelsMaleRecovery of FunctionSevere Acute MalnutritionWeight GainBioelectrical impedance analysisBody compositionBurkina FasoChildrenReady-to-use therapeutic foodSevere acute malnutrition

Identifiers

PMID32184026
PMCPMC11346517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.