Evidence map›Paper›PMID 32183900›Full record

ArticleArthritis research & therapy2020

The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H

Sonia Nasi, Driss Ehirchiou, Athanasia Chatzianastasiou, Noriyuki Nagahara, Andreas Papapetropoulos, Jessica Bertrand, Giuseppe Cirino, Alexander So, Nathalie Busso

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Slow HBiomolecules · 2024
    Article
  5. Signaling Paradigms of HAntioxidants (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Reduced Levels of HAntioxidants (Basel, Switzerland) · 2022
    Article
  11. The Gasotransmitter Hydrogen Sulfide (HAntioxidants (Basel, Switzerland) · 2021
    Article
  12. Article
  13. Hydrogen Sulfide and the Immune System.Advances in experimental medicine and biology · 2021
    Article
  14. Article
  15. Experimental Therapeutics for the Treatment of Osteoarthritis.Journal of experimental pharmacology · 2021
    Review
  16. Review
  17. Article
  18. Article
  19. HBiomolecules · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 5 countries.

Sonia NasiService of Rheumatology, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Driss EhirchiouService of Rheumatology, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Athanasia ChatzianastasiouFirst Department of Critical Care and Pulmonary Services, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Noriyuki NagaharaIsotope Research Center, Nippon Medical School, Tokyo, Japan.
Andreas PapapetropoulosLaboratory of Pharmacology, Faculty of Pharmacy, University of Athens, Athens, Greece.
Jessica BertrandDepartment of Orthopaedic Surgery, Otto-von-Guericke University, Magdeburg, Germany.
Giuseppe CirinoDepartment of Pharmacy, University of Naples Federico II, Naples, Italy.
Alexander SoService of Rheumatology, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Nathalie BussoService of Rheumatology, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland. Nathalie.Busso@chuv.ch.
University Hospital of Lausanne · CHBiomedical Research Foundation of the Academy of Athens · GRNational and Kapodistrian University of Athens · GRNippon Medical School · JPOtto-von-Guericke University Magdeburg · DEUniversity of Lausanne · CHUniversity of Naples Federico II · IT

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 310030-130085
6 · The paper itself

Abstract

backgroundOsteoarthritis (OA) is characterized by the formation and deposition of calcium-containing crystals in joint tissues, but the underlying mechanisms are poorly understood. The gasotransmitter hydrogen sulfide (H

methods3-MST expression was analyzed in cartilage from patients with different OA degrees, and in cartilage stimulated with hydroxyapatite (HA) crystals. The modulation of 3-MST expression in vivo was studied in the meniscectomy (MNX) model of murine OA, by comparing sham-operated to MNX knee cartilage. The role of 3-MST was investigated by quantifying joint calcification and cartilage degradation in WT and 3-MST

results3-MST expression in human cartilage negatively correlated with calcification and OA severity, and diminished upon HA stimulation. In accordance, cartilage from menisectomized OA knees revealed decreased 3-MST if compared to sham-operated healthy knees. Moreover, 3-MST

conclusion3-MST-generated H

Indexed as

AgedAged, 80 and overAnimalsCalcinosisCartilage, ArticularChondrocytesFemaleHumansHydrogen SulfideInterleukin-6MeniscectomyMice, Inbred C57BLMice, KnockoutMiddle AgedOsteoarthritis, KneeProtective Agents3-mercaptopyruvate sulphurtransferaseHydrogen SulfideInterleukin-6Protective AgentsSulfurtransferasesAnimal modelCalcium-containing crystalsChondrocyte calcificationHydrogen sulfideOsteoarthritis

Identifiers

PMID32183900
PMCPMC7077027
OpenAlexW3012286483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.