Evidence map›Paper›PMID 32183895›Full record

ArticleTrials2020

Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial.

Forough Shayesteh, Fatemeh Haidari, Ali Akbar Shayesteh, Javad Mohammadi-Asl, Kambiz Ahmadi-Angali

Abstract readClinical Trial Protocol
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Enhancing oral delivery of plant-derived vesicles for colitis.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Forough ShayestehDepartment of Nutrition, Nutrition, and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Fatemeh HaidariDepartment of Nutrition, Nutrition, and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Haidari58@gmail.com.
Ali Akbar ShayestehAlimentary Tract Research Center, Imam Khomeini Hospital, The School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Javad Mohammadi-AslDepartment of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Kambiz Ahmadi-AngaliFaculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Funding

Ahvaz Jundishapur University of Medical Sciences NRC-9722
6 · The paper itself

Abstract

backgroundAs a lifetime disorder, ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that affects quality of life and also demands long-term interventions. In spite of considerable side effects and sometimes restricted uses, efficient medications are available for UC treatment. Some in vitro and in vivo examinations have correspondingly introduced ginger and its active components with antioxidant, anti-inflammatory, and anti-ulcerative properties. Therefore, this trial aims to evaluate the effect of ginger supplementation on patients with active UC.

methodsThis study will be a 12-week, double-blind, parallel-group, randomized, controlled trial (RCT) in which 44 patients will be allocated to ginger and placebo groups receiving basic routine treatments plus ginger or placebo capsules, respectively. The primary outcomes are inflammatory markers (TNF-α and hs-CRP) and total antioxidant capacity. DISCUSSION: The findings of this trial will provide evidence on the effect of ginger on patients with active UC.

trial registrationIranian Registry of Clinical Trials, IRCT20190129042552N1. Registered on 21 June 2019.

Indexed as

Anti-Inflammatory AgentsAntioxidantsAnti-Ulcer AgentsBiomarkersColitis, UlcerativeC-Reactive ProteinDietary SupplementsDouble-Blind MethodHumansIranPlant PreparationsQuality of LifeRandomized Controlled Trials as TopicRemission InductionTumor Necrosis Factor-alphaZingiber officinaleAnti-Inflammatory AgentsAntioxidantsAnti-Ulcer AgentsBiomarkersC-Reactive ProteinPlant PreparationsTumor Necrosis Factor-alphaGingerInflammationUlcerative colitis

Identifiers

PMID32183895
PMCPMC7079449

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.