SynthesisReproductive biology and endocrinology : RB&E2020
Risk of hypertension in women with polycystic ovary syndrome: a systematic review, meta-analysis and meta-regression.
Synthesis in Reproductive biology and endocrinology : RB&E, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 3 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Polycystic ovary syndrome with stroke, hypertension, and cardiovascular diseases: a systematic review and meta-analysis.BMC women's health · 2025Pooled it
- Validity of administrative health data case definitions for identifying polycystic ovary syndrome: a systematic review and meta-analysis.Human reproduction (Oxford, England) · 2025Pooled it
- Cardiovascular Events Among Women with Premature Ovarian Insufficiency: A Systematic Review and Meta-Analysis.Reviews in cardiovascular medicine · 2023Pooled it
- Childbirth experiences in women with polycystic ovary syndrome: A cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Trial
- Bloodletting has no effect on the blood pressure abnormalities of hyperandrogenic women taking oral contraceptives in a randomized clinical trial.Scientific reports · 2021Trial
- Gut dysbiosis, blood pressure regulation, and cardiometabolic risk in polyendocrine metabolic ovarian syndrome (PMOS).Reviews in endocrine & metabolic disorders · 2026Review
- Maternal Metabolic Dysfunction and Uteroplacental Adaptation in Polyendocrine Metabolic Ovarian Syndrome Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Potential Mechanisms Linking Excessive Testosterone to PMOS: Insights from Network Toxicology and Machine Learning.Metabolites · 2026Article
- Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women.American journal of physiology. Heart and circulatory physiology · 2026Article
- Observational
- The immunogenetic basis of ovarian apoptosis: from TNF-α polymorphisms and signaling pathways to glucocorticoid-mediated rescue.Journal of ovarian research · 2026Review
- Hypertension in Women Across the Life Cycle: Unique Aspects and Challenges.Current hypertension reports · 2026Review
- 24-hour ambulatory blood pressure and associated factors in women with polycystic ovary syndrome compared with ovulatory controls.Scientific reports · 2026Article
- Prediction of cardiovascular disease risk in women and individuals with polycystic ovary syndrome using the American Heart Association PREVENT model: A long-term population-based cohort study.American journal of preventive cardiology · 2026Article
- Peripartum Telehealth Care Utilization During the COVID-19 Pandemic, by Hypertension Status, PCORnet®, 2018 to 2023.Medical care · 2026Article
- Trajectories of menstrual symptoms and blood pressure in midlife: a prospective cohort study on Australian women.Journal of human hypertension · 2025Article
- Hypertension and Polycystic Ovary Syndrome Among Women in a Nationwide Electronic Health Records Dataset in the United States.Maternal and child health journal · 2025Article
- Risk Factors for Hypertension in Polycystic Ovary Syndrome: Evidence from a Retrospective Study.Life (Basel, Switzerland) · 2025Article
- The Particularities of Arterial Hypertension in Female Sex: From Pathophysiology to Therapeutic Management.Journal of clinical medicine · 2025Review
- The impact of androgens on cardiovascular control mechanisms in polycystic ovary syndrome: Recent advances and translational approaches.The Journal of physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA limited number of publications have assessed the prevalence of hypertension (HTN) in polycystic ovary syndrome (PCOS) patients with inconclusive results. Since in general populations the occurrence of hypertension is related to age per se, we investigated the prevalence (P) / relative risk (RR) of HTN in pooled patients with PCOS, vs control population among reproductive age women with PCOS, compared to menopause/aging patients.
methodsPubMed, Scopus, ScienceDirect, web of science, and Google scholar were systematically searched for retrieving observational studies published from inception to April 2019 investigating the HTN in patients with PCOS. The primary outcome of interest was pooled P and RR of HTN in reproductive and menopausal/aging women with PCOS compared to control population.
resultsThe pooled prevalence of HTN in reproductive and menopausal/aging women with PCOS was higher than in the control population [(Pooled P: 0.15, 95% CI: 0.12-0.18 vs. Pooled P: 0.09, 95% CI: 0.08-0.10) and (Pooled P: 0.49, 95% CI: 0.28-0.70 vs. Pooled P: 0.40, 95% CI: 0.22-0.57), respectively]. Compared to the control population, pooled relative risk (RR) of HTN patients was increased only in reproductive age PCOS (1.70-fold, 95% CI: 1.43-2.07) but not in menopausal/aging patients who had PCOS during their reproductive years. The same results were obtained for subgroups of population-based studies. Meta-regression analysis of population-based studies showed that the RR of HTN in reproductive age PCOS patients was 1.76-fold than menopausal/aging PCOS patients (P = 0.262).
conclusionThis meta-analysis confirms a greater risk of HTN in PCOS patients but demonstrates that this risk is increased only in reproductive age women with PCOS, indicating that after menopause, having a history of PCOS may not be as an important predisposing factor for developing HTN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.